Molecular docking analysis of flavonoids with aldose reductase

Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature,...

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Detalles Bibliográficos
Autores principales: Kannayiram, Kasthuri, Umapathy, Vidhya Rekha, Chamundeswari, Y, Fathima, JH, Govindan, Ramajayam, Palanisamy, Chella Perumal, Veeraraghavan, Vishnu Priya, Jayaraman, Selvaraj, Rajagopal, Ponnulakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722430/
https://www.ncbi.nlm.nih.gov/pubmed/36518142
http://dx.doi.org/10.6026/97320630018180
Descripción
Sumario:Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature, including anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, and anti-HIV properties. 15 naturally occurring flavonoids docked with the selected target aldose reductase. We report the optimal binding of Acumitin, Agathisflavone, Agehoustin B, and alpha-Toxicarol with aldose reductase for further consideration in drug discovery for T2DM.

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