Molecular docking analysis of flavonoids with aldose reductase

Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature,...

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Autores principales: Kannayiram, Kasthuri, Umapathy, Vidhya Rekha, Chamundeswari, Y, Fathima, JH, Govindan, Ramajayam, Palanisamy, Chella Perumal, Veeraraghavan, Vishnu Priya, Jayaraman, Selvaraj, Rajagopal, Ponnulakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722430/
https://www.ncbi.nlm.nih.gov/pubmed/36518142
http://dx.doi.org/10.6026/97320630018180
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author Kannayiram, Kasthuri
Umapathy, Vidhya Rekha
Chamundeswari, Y
Fathima, JH
Govindan, Ramajayam
Palanisamy, Chella Perumal
Veeraraghavan, Vishnu Priya
Jayaraman, Selvaraj
Rajagopal, Ponnulakshmi
author_facet Kannayiram, Kasthuri
Umapathy, Vidhya Rekha
Chamundeswari, Y
Fathima, JH
Govindan, Ramajayam
Palanisamy, Chella Perumal
Veeraraghavan, Vishnu Priya
Jayaraman, Selvaraj
Rajagopal, Ponnulakshmi
author_sort Kannayiram, Kasthuri
collection PubMed
description Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature, including anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, and anti-HIV properties. 15 naturally occurring flavonoids docked with the selected target aldose reductase. We report the optimal binding of Acumitin, Agathisflavone, Agehoustin B, and alpha-Toxicarol with aldose reductase for further consideration in drug discovery for T2DM.
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spelling pubmed-97224302022-12-13 Molecular docking analysis of flavonoids with aldose reductase Kannayiram, Kasthuri Umapathy, Vidhya Rekha Chamundeswari, Y Fathima, JH Govindan, Ramajayam Palanisamy, Chella Perumal Veeraraghavan, Vishnu Priya Jayaraman, Selvaraj Rajagopal, Ponnulakshmi Bioinformation Research Article Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature, including anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, and anti-HIV properties. 15 naturally occurring flavonoids docked with the selected target aldose reductase. We report the optimal binding of Acumitin, Agathisflavone, Agehoustin B, and alpha-Toxicarol with aldose reductase for further consideration in drug discovery for T2DM. Biomedical Informatics 2022-03-31 /pmc/articles/PMC9722430/ /pubmed/36518142 http://dx.doi.org/10.6026/97320630018180 Text en © 2022 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Kannayiram, Kasthuri
Umapathy, Vidhya Rekha
Chamundeswari, Y
Fathima, JH
Govindan, Ramajayam
Palanisamy, Chella Perumal
Veeraraghavan, Vishnu Priya
Jayaraman, Selvaraj
Rajagopal, Ponnulakshmi
Molecular docking analysis of flavonoids with aldose reductase
title Molecular docking analysis of flavonoids with aldose reductase
title_full Molecular docking analysis of flavonoids with aldose reductase
title_fullStr Molecular docking analysis of flavonoids with aldose reductase
title_full_unstemmed Molecular docking analysis of flavonoids with aldose reductase
title_short Molecular docking analysis of flavonoids with aldose reductase
title_sort molecular docking analysis of flavonoids with aldose reductase
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722430/
https://www.ncbi.nlm.nih.gov/pubmed/36518142
http://dx.doi.org/10.6026/97320630018180
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