Hypophosphatemia Due to Increased Effector Cell Metabolic Activity Is Associated with Neurotoxicity Symptoms in CD19-Targeted CAR T-cell Therapy

A major complication of chimeric antigen receptor (CAR) T-cell therapy is immune effector cell–associated neurotoxicity syndrome (ICANS), which presents as aphasia, confusion, weakness, somnolence, seizures, and coma. This is similar to the neurologic manifestations of hypophosphatemia, which can re...

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Detalles Bibliográficos
Autores principales: Tang, Jack Pengfei, Peters, Cole W., Quiros, Crystal, Wang, Xiaoyan, Klomhaus, Alexandra M., Yamada, Reiko E., Timmerman, John M., Moore, Theodore B., Nowicki, Theodore S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Priority Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722515/
https://www.ncbi.nlm.nih.gov/pubmed/36259217
http://dx.doi.org/10.1158/2326-6066.CIR-22-0418

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