Spatiotemporal Control of Vascular Ca(V)1.2 by α1(C) S1928 Phosphorylation

L-type Ca(V)1.2 channels undergo cooperative gating to regulate cell function, although mechanisms are unclear. This study tests the hypothesis that phosphorylation of the Ca(V)1.2 pore-forming subunit α1(C) at S1928 mediates vascular Ca(V)1.2 cooperativity during diabetic hyperglycemia. METHODS: A...

Descripción completa

Detalles Bibliográficos
Autores principales: Martín-Aragón Baudel, Miguel, Flores-Tamez, Victor A., Hong, Junyoung, Reddy, Gopyreddy R., Maillard, Pauline, Burns, Abby E., Man, Kwun Nok Mimi, Sasse, Kent C., Ward, Sean M., Catterall, William A., Bers, Donald M., Hell, Johannes W., Nieves-Cintrón, Madeline, Navedo, Manuel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722584/
https://www.ncbi.nlm.nih.gov/pubmed/36345826
http://dx.doi.org/10.1161/CIRCRESAHA.122.321479

Ejemplares similares

Ejemplares similares