Longitudinal stability in working memory and frontal activity in relation to general brain maintenance

Cognitive functions are well-preserved for some older individuals, but the underlying brain mechanisms remain disputed. Here, 5-year longitudinal 3-back in-scanner and offline data classified individuals in a healthy older sample (baseline age = 64–68 years) into having stable or declining working-m...

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Autores principales: Nyberg, Lars, Karalija, Nina, Papenberg, Goran, Salami, Alireza, Andersson, Micael, Pedersen, Robin, Vikner, Tomas, Garrett, Douglas D., Riklund, Katrine, Wåhlin, Anders, Lövdén, Martin, Lindenberger, Ulman, Bäckman, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722656/
https://www.ncbi.nlm.nih.gov/pubmed/36470934
http://dx.doi.org/10.1038/s41598-022-25503-9
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author Nyberg, Lars
Karalija, Nina
Papenberg, Goran
Salami, Alireza
Andersson, Micael
Pedersen, Robin
Vikner, Tomas
Garrett, Douglas D.
Riklund, Katrine
Wåhlin, Anders
Lövdén, Martin
Lindenberger, Ulman
Bäckman, Lars
author_facet Nyberg, Lars
Karalija, Nina
Papenberg, Goran
Salami, Alireza
Andersson, Micael
Pedersen, Robin
Vikner, Tomas
Garrett, Douglas D.
Riklund, Katrine
Wåhlin, Anders
Lövdén, Martin
Lindenberger, Ulman
Bäckman, Lars
author_sort Nyberg, Lars
collection PubMed
description Cognitive functions are well-preserved for some older individuals, but the underlying brain mechanisms remain disputed. Here, 5-year longitudinal 3-back in-scanner and offline data classified individuals in a healthy older sample (baseline age = 64–68 years) into having stable or declining working-memory (WM). Consistent with a vital role of the prefrontal cortex (PFC), WM stability or decline was related to maintained or reduced longitudinal PFC functional responses. Subsequent analyses of imaging markers of general brain maintenance revealed higher levels in the stable WM group on measures of neurotransmission and vascular health. Also, categorical and continuous analyses showed that rate of WM decline was related to global (ventricles) and local (hippocampus) measures of neuronal integrity. Thus, our findings support a role of the PFC as well as general brain maintenance in explaining heterogeneity in longitudinal WM trajectories in aging.
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spelling pubmed-97226562022-12-07 Longitudinal stability in working memory and frontal activity in relation to general brain maintenance Nyberg, Lars Karalija, Nina Papenberg, Goran Salami, Alireza Andersson, Micael Pedersen, Robin Vikner, Tomas Garrett, Douglas D. Riklund, Katrine Wåhlin, Anders Lövdén, Martin Lindenberger, Ulman Bäckman, Lars Sci Rep Article Cognitive functions are well-preserved for some older individuals, but the underlying brain mechanisms remain disputed. Here, 5-year longitudinal 3-back in-scanner and offline data classified individuals in a healthy older sample (baseline age = 64–68 years) into having stable or declining working-memory (WM). Consistent with a vital role of the prefrontal cortex (PFC), WM stability or decline was related to maintained or reduced longitudinal PFC functional responses. Subsequent analyses of imaging markers of general brain maintenance revealed higher levels in the stable WM group on measures of neurotransmission and vascular health. Also, categorical and continuous analyses showed that rate of WM decline was related to global (ventricles) and local (hippocampus) measures of neuronal integrity. Thus, our findings support a role of the PFC as well as general brain maintenance in explaining heterogeneity in longitudinal WM trajectories in aging. Nature Publishing Group UK 2022-12-05 /pmc/articles/PMC9722656/ /pubmed/36470934 http://dx.doi.org/10.1038/s41598-022-25503-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nyberg, Lars
Karalija, Nina
Papenberg, Goran
Salami, Alireza
Andersson, Micael
Pedersen, Robin
Vikner, Tomas
Garrett, Douglas D.
Riklund, Katrine
Wåhlin, Anders
Lövdén, Martin
Lindenberger, Ulman
Bäckman, Lars
Longitudinal stability in working memory and frontal activity in relation to general brain maintenance
title Longitudinal stability in working memory and frontal activity in relation to general brain maintenance
title_full Longitudinal stability in working memory and frontal activity in relation to general brain maintenance
title_fullStr Longitudinal stability in working memory and frontal activity in relation to general brain maintenance
title_full_unstemmed Longitudinal stability in working memory and frontal activity in relation to general brain maintenance
title_short Longitudinal stability in working memory and frontal activity in relation to general brain maintenance
title_sort longitudinal stability in working memory and frontal activity in relation to general brain maintenance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722656/
https://www.ncbi.nlm.nih.gov/pubmed/36470934
http://dx.doi.org/10.1038/s41598-022-25503-9
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