Cargando…

Planar aggregation of the influenza viral fusion peptide alters membrane structure and hydration, promoting poration

To infect, enveloped viruses employ spike protein, spearheaded by its amphipathic fusion peptide (FP), that upon activation extends out from the viral surface to embed into the target cellular membrane. Here we report that synthesized influenza virus FPs are membrane active, generating pores in gian...

Descripción completa

Detalles Bibliográficos
Autores principales: Rice, Amy, Haldar, Sourav, Wang, Eric, Blank, Paul S., Akimov, Sergey A., Galimzyanov, Timur R., Pastor, Richard W., Zimmerberg, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722698/
https://www.ncbi.nlm.nih.gov/pubmed/36470871
http://dx.doi.org/10.1038/s41467-022-34576-z

Ejemplares similares