The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway

Despite the high prevalence of osteoarthritis (OA) in older populations, disease-modifying OA drugs (DMOADs) are still lacking. This study was performed to investigate the effects and mechanisms of the small molecular drug salicin (SA) on OA progression. Primary rat chondrocytes were stimulated with...

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Detalles Bibliográficos
Autores principales: Zhu, Zhenglin, Gao, Shengqiang, Chen, Cheng, Xu, Wei, Xiao, Pengcheng, Chen, Zhiyu, Du, Chengcheng, Chen, Bowen, Gao, Yan, Wang, Chunli, Liao, Junyi, Huang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722708/
https://www.ncbi.nlm.nih.gov/pubmed/36357568
http://dx.doi.org/10.1038/s12276-022-00879-w

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