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Brainstem tumors may increase the impairment of behavioral emotional cognition in children

PURPOSE: It remains unclear as to whether patients with brainstem tumor experience complex neuropsychiatric problems. In this cohort study, we specifically investigated behavioral, emotional and cognitive symptoms in pediatric patients with brainstem glioma and healthy individuals. METHODS: A total...

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Autores principales: Jia, Heyuan, Zhang, Peng, Gu, Guocan, Li, Tian, Jiang, Zhuang, Wu, Zhen, Wang, Liang, Zhang, Junting, Duan, Yunyun, Liu, Yaou, Yang, Feng, Qin, Shaozheng, Zhang, Liwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722802/
https://www.ncbi.nlm.nih.gov/pubmed/36333568
http://dx.doi.org/10.1007/s11060-022-04161-x
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author Jia, Heyuan
Zhang, Peng
Gu, Guocan
Li, Tian
Jiang, Zhuang
Wu, Zhen
Wang, Liang
Zhang, Junting
Duan, Yunyun
Liu, Yaou
Yang, Feng
Qin, Shaozheng
Zhang, Liwei
author_facet Jia, Heyuan
Zhang, Peng
Gu, Guocan
Li, Tian
Jiang, Zhuang
Wu, Zhen
Wang, Liang
Zhang, Junting
Duan, Yunyun
Liu, Yaou
Yang, Feng
Qin, Shaozheng
Zhang, Liwei
author_sort Jia, Heyuan
collection PubMed
description PURPOSE: It remains unclear as to whether patients with brainstem tumor experience complex neuropsychiatric problems. In this cohort study, we specifically investigated behavioral, emotional and cognitive symptoms in pediatric patients with brainstem glioma and healthy individuals. METHODS: A total of 146 patients with pediatric brainstem tumors (aged 4–18 years old) and 46 age-matched healthy children were recruited to assess their behaviors and emotions examined by the Child Behavior Checklist. A variety of clinical factors were also analyzed. RESULTS: There were significant differences in most behavioral and emotional symptoms between pediatric patients and healthy subjects. Moreover, patients with pons tumors exhibited significantly higher scores than patients with medulla oblongata tumors (p = 0.012), particularly in concerning the syndrome categories of Withdrawn (p = 0.043), Anxious/depressed symptoms (p = 0.046), Thought Problems (p = 0.004), Attention deficits (p = 0.008), Externalizing problems (p = 0.013), and Aggressive behavior (p = 0.004). A tumor body located in the pontine (p = 0.01, OR = 4.5, 95% CI = 1.4–14.059) or DIPG in the midbrain (p = 0.002, OR = 3.818, 95% CI = 1.629–8.948) appears to act as a risk factor that is associated with more problems in patients with neuropsychiatric symptoms. CONCLUSIONS: Pediatric patients with brainstem tumors exhibit severe behavioral and emotional problems. Tumor invades the pontine and midbrain act a risk factor with more problems. It suggests that structural and functional abnormalities in the brainstem will cause prolonged behavioral problems and emotional-cognitive dysfunctions in young children. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11060-022-04161-x.
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spelling pubmed-97228022022-12-07 Brainstem tumors may increase the impairment of behavioral emotional cognition in children Jia, Heyuan Zhang, Peng Gu, Guocan Li, Tian Jiang, Zhuang Wu, Zhen Wang, Liang Zhang, Junting Duan, Yunyun Liu, Yaou Yang, Feng Qin, Shaozheng Zhang, Liwei J Neurooncol Research PURPOSE: It remains unclear as to whether patients with brainstem tumor experience complex neuropsychiatric problems. In this cohort study, we specifically investigated behavioral, emotional and cognitive symptoms in pediatric patients with brainstem glioma and healthy individuals. METHODS: A total of 146 patients with pediatric brainstem tumors (aged 4–18 years old) and 46 age-matched healthy children were recruited to assess their behaviors and emotions examined by the Child Behavior Checklist. A variety of clinical factors were also analyzed. RESULTS: There were significant differences in most behavioral and emotional symptoms between pediatric patients and healthy subjects. Moreover, patients with pons tumors exhibited significantly higher scores than patients with medulla oblongata tumors (p = 0.012), particularly in concerning the syndrome categories of Withdrawn (p = 0.043), Anxious/depressed symptoms (p = 0.046), Thought Problems (p = 0.004), Attention deficits (p = 0.008), Externalizing problems (p = 0.013), and Aggressive behavior (p = 0.004). A tumor body located in the pontine (p = 0.01, OR = 4.5, 95% CI = 1.4–14.059) or DIPG in the midbrain (p = 0.002, OR = 3.818, 95% CI = 1.629–8.948) appears to act as a risk factor that is associated with more problems in patients with neuropsychiatric symptoms. CONCLUSIONS: Pediatric patients with brainstem tumors exhibit severe behavioral and emotional problems. Tumor invades the pontine and midbrain act a risk factor with more problems. It suggests that structural and functional abnormalities in the brainstem will cause prolonged behavioral problems and emotional-cognitive dysfunctions in young children. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11060-022-04161-x. Springer US 2022-11-04 2022 /pmc/articles/PMC9722802/ /pubmed/36333568 http://dx.doi.org/10.1007/s11060-022-04161-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Jia, Heyuan
Zhang, Peng
Gu, Guocan
Li, Tian
Jiang, Zhuang
Wu, Zhen
Wang, Liang
Zhang, Junting
Duan, Yunyun
Liu, Yaou
Yang, Feng
Qin, Shaozheng
Zhang, Liwei
Brainstem tumors may increase the impairment of behavioral emotional cognition in children
title Brainstem tumors may increase the impairment of behavioral emotional cognition in children
title_full Brainstem tumors may increase the impairment of behavioral emotional cognition in children
title_fullStr Brainstem tumors may increase the impairment of behavioral emotional cognition in children
title_full_unstemmed Brainstem tumors may increase the impairment of behavioral emotional cognition in children
title_short Brainstem tumors may increase the impairment of behavioral emotional cognition in children
title_sort brainstem tumors may increase the impairment of behavioral emotional cognition in children
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722802/
https://www.ncbi.nlm.nih.gov/pubmed/36333568
http://dx.doi.org/10.1007/s11060-022-04161-x
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