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Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage

Signal-Peptide Peptidase Like-3 (SPPL3) is an intramembrane cleaving aspartyl protease that causes secretion of extracellular domains from type-II transmembrane proteins. Numerous Golgi-localized glycosidases and glucosyltransferases have been identified as physiological SPPL3 substrates. By SPPL3 d...

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Detalles Bibliográficos
Autores principales:	Papadopoulou, Alkmini A., Stelzer, Walter, Silber, Mara, Schlosser, Christine, Spitz, Charlotte, Haug-Kröper, Martina, Straub, Tobias, Müller, Stephan A., Lichtenthaler, Stefan F., Muhle-Goll, Claudia, Langosch, Dieter, Fluhrer, Regina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722940/ https://www.ncbi.nlm.nih.gov/pubmed/36470941 http://dx.doi.org/10.1038/s41598-022-24772-8

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