Cargando…

Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma

BACKGROUND: Onychopapilloma is generally recognized as a benign tumor of the nail bed and distal matrix. However, the origin of onychopapilloma has not been explained yet. OBJECTIVE: To clarify the origin of onychopapilloma, we detected the expression patterns of hair-related keratins and epithelial...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Mengxi, Li, Fang, Wang, Xiaoqing, Liu, Zhenru, Wong, Hoi Shiwn, Zhou, Yuan, Wang, Daguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722942/
https://www.ncbi.nlm.nih.gov/pubmed/36482914
http://dx.doi.org/10.3389/fmed.2022.1059624
_version_ 1784844069048942592
author Liu, Mengxi
Li, Fang
Wang, Xiaoqing
Liu, Zhenru
Wong, Hoi Shiwn
Zhou, Yuan
Wang, Daguang
author_facet Liu, Mengxi
Li, Fang
Wang, Xiaoqing
Liu, Zhenru
Wong, Hoi Shiwn
Zhou, Yuan
Wang, Daguang
author_sort Liu, Mengxi
collection PubMed
description BACKGROUND: Onychopapilloma is generally recognized as a benign tumor of the nail bed and distal matrix. However, the origin of onychopapilloma has not been explained yet. OBJECTIVE: To clarify the origin of onychopapilloma, we detected the expression patterns of hair-related keratins and epithelial keratins, which are expressed specifically in the nail unit. MATERIALS AND METHODS: The clinical and histopathologic features of 11 patients with onychopapilloma were analyzed, and the expression patterns of hair-related and epithelial keratins were detected. RESULTS: Histologically, all subjects showed acanthosis, papillomatosis and matrix metaplasia within the nail bed. Immunohistochemically, the expression pattern of keratins in our standard nail unit was consistent with previous reports. “Nail matrix-related keratins” HK31, HK34, HK85, and HK86 were only expressed in the nail matrix, and “Nail bed-related keratins” HK75 and K6/K16 were only expressed in the nail bed. However, in onychopapilloma, whether adjacent to the matrix or in the distal nail bed, all cases were positive for nail bed-related keratins and HK31 but negative for other nail matrix-related keratins. CONCLUSION: Our study suggests that onychopapilloma may originate from the nail bed rather than the nail matrix. Furthermore, the expression of nail bed-related keratins and HK31 could be used as diagnostic markers of onychopapilloma.
format Online
Article
Text
id pubmed-9722942
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97229422022-12-07 Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma Liu, Mengxi Li, Fang Wang, Xiaoqing Liu, Zhenru Wong, Hoi Shiwn Zhou, Yuan Wang, Daguang Front Med (Lausanne) Medicine BACKGROUND: Onychopapilloma is generally recognized as a benign tumor of the nail bed and distal matrix. However, the origin of onychopapilloma has not been explained yet. OBJECTIVE: To clarify the origin of onychopapilloma, we detected the expression patterns of hair-related keratins and epithelial keratins, which are expressed specifically in the nail unit. MATERIALS AND METHODS: The clinical and histopathologic features of 11 patients with onychopapilloma were analyzed, and the expression patterns of hair-related and epithelial keratins were detected. RESULTS: Histologically, all subjects showed acanthosis, papillomatosis and matrix metaplasia within the nail bed. Immunohistochemically, the expression pattern of keratins in our standard nail unit was consistent with previous reports. “Nail matrix-related keratins” HK31, HK34, HK85, and HK86 were only expressed in the nail matrix, and “Nail bed-related keratins” HK75 and K6/K16 were only expressed in the nail bed. However, in onychopapilloma, whether adjacent to the matrix or in the distal nail bed, all cases were positive for nail bed-related keratins and HK31 but negative for other nail matrix-related keratins. CONCLUSION: Our study suggests that onychopapilloma may originate from the nail bed rather than the nail matrix. Furthermore, the expression of nail bed-related keratins and HK31 could be used as diagnostic markers of onychopapilloma. Frontiers Media S.A. 2022-11-22 /pmc/articles/PMC9722942/ /pubmed/36482914 http://dx.doi.org/10.3389/fmed.2022.1059624 Text en Copyright © 2022 Liu, Li, Wang, Liu, Wong, Zhou and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Liu, Mengxi
Li, Fang
Wang, Xiaoqing
Liu, Zhenru
Wong, Hoi Shiwn
Zhou, Yuan
Wang, Daguang
Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma
title Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma
title_full Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma
title_fullStr Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma
title_full_unstemmed Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma
title_short Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma
title_sort expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: the significance of clarifying the origin of onychopapilloma
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722942/
https://www.ncbi.nlm.nih.gov/pubmed/36482914
http://dx.doi.org/10.3389/fmed.2022.1059624
work_keys_str_mv AT liumengxi expressionpatternsofhairrelatedkeratinsandepithelialkeratinsinonychopapillomathesignificanceofclarifyingtheoriginofonychopapilloma
AT lifang expressionpatternsofhairrelatedkeratinsandepithelialkeratinsinonychopapillomathesignificanceofclarifyingtheoriginofonychopapilloma
AT wangxiaoqing expressionpatternsofhairrelatedkeratinsandepithelialkeratinsinonychopapillomathesignificanceofclarifyingtheoriginofonychopapilloma
AT liuzhenru expressionpatternsofhairrelatedkeratinsandepithelialkeratinsinonychopapillomathesignificanceofclarifyingtheoriginofonychopapilloma
AT wonghoishiwn expressionpatternsofhairrelatedkeratinsandepithelialkeratinsinonychopapillomathesignificanceofclarifyingtheoriginofonychopapilloma
AT zhouyuan expressionpatternsofhairrelatedkeratinsandepithelialkeratinsinonychopapillomathesignificanceofclarifyingtheoriginofonychopapilloma
AT wangdaguang expressionpatternsofhairrelatedkeratinsandepithelialkeratinsinonychopapillomathesignificanceofclarifyingtheoriginofonychopapilloma