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Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma
BACKGROUND: Onychopapilloma is generally recognized as a benign tumor of the nail bed and distal matrix. However, the origin of onychopapilloma has not been explained yet. OBJECTIVE: To clarify the origin of onychopapilloma, we detected the expression patterns of hair-related keratins and epithelial...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722942/ https://www.ncbi.nlm.nih.gov/pubmed/36482914 http://dx.doi.org/10.3389/fmed.2022.1059624 |
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author | Liu, Mengxi Li, Fang Wang, Xiaoqing Liu, Zhenru Wong, Hoi Shiwn Zhou, Yuan Wang, Daguang |
author_facet | Liu, Mengxi Li, Fang Wang, Xiaoqing Liu, Zhenru Wong, Hoi Shiwn Zhou, Yuan Wang, Daguang |
author_sort | Liu, Mengxi |
collection | PubMed |
description | BACKGROUND: Onychopapilloma is generally recognized as a benign tumor of the nail bed and distal matrix. However, the origin of onychopapilloma has not been explained yet. OBJECTIVE: To clarify the origin of onychopapilloma, we detected the expression patterns of hair-related keratins and epithelial keratins, which are expressed specifically in the nail unit. MATERIALS AND METHODS: The clinical and histopathologic features of 11 patients with onychopapilloma were analyzed, and the expression patterns of hair-related and epithelial keratins were detected. RESULTS: Histologically, all subjects showed acanthosis, papillomatosis and matrix metaplasia within the nail bed. Immunohistochemically, the expression pattern of keratins in our standard nail unit was consistent with previous reports. “Nail matrix-related keratins” HK31, HK34, HK85, and HK86 were only expressed in the nail matrix, and “Nail bed-related keratins” HK75 and K6/K16 were only expressed in the nail bed. However, in onychopapilloma, whether adjacent to the matrix or in the distal nail bed, all cases were positive for nail bed-related keratins and HK31 but negative for other nail matrix-related keratins. CONCLUSION: Our study suggests that onychopapilloma may originate from the nail bed rather than the nail matrix. Furthermore, the expression of nail bed-related keratins and HK31 could be used as diagnostic markers of onychopapilloma. |
format | Online Article Text |
id | pubmed-9722942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97229422022-12-07 Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma Liu, Mengxi Li, Fang Wang, Xiaoqing Liu, Zhenru Wong, Hoi Shiwn Zhou, Yuan Wang, Daguang Front Med (Lausanne) Medicine BACKGROUND: Onychopapilloma is generally recognized as a benign tumor of the nail bed and distal matrix. However, the origin of onychopapilloma has not been explained yet. OBJECTIVE: To clarify the origin of onychopapilloma, we detected the expression patterns of hair-related keratins and epithelial keratins, which are expressed specifically in the nail unit. MATERIALS AND METHODS: The clinical and histopathologic features of 11 patients with onychopapilloma were analyzed, and the expression patterns of hair-related and epithelial keratins were detected. RESULTS: Histologically, all subjects showed acanthosis, papillomatosis and matrix metaplasia within the nail bed. Immunohistochemically, the expression pattern of keratins in our standard nail unit was consistent with previous reports. “Nail matrix-related keratins” HK31, HK34, HK85, and HK86 were only expressed in the nail matrix, and “Nail bed-related keratins” HK75 and K6/K16 were only expressed in the nail bed. However, in onychopapilloma, whether adjacent to the matrix or in the distal nail bed, all cases were positive for nail bed-related keratins and HK31 but negative for other nail matrix-related keratins. CONCLUSION: Our study suggests that onychopapilloma may originate from the nail bed rather than the nail matrix. Furthermore, the expression of nail bed-related keratins and HK31 could be used as diagnostic markers of onychopapilloma. Frontiers Media S.A. 2022-11-22 /pmc/articles/PMC9722942/ /pubmed/36482914 http://dx.doi.org/10.3389/fmed.2022.1059624 Text en Copyright © 2022 Liu, Li, Wang, Liu, Wong, Zhou and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Liu, Mengxi Li, Fang Wang, Xiaoqing Liu, Zhenru Wong, Hoi Shiwn Zhou, Yuan Wang, Daguang Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma |
title | Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma |
title_full | Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma |
title_fullStr | Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma |
title_full_unstemmed | Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma |
title_short | Expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: The significance of clarifying the origin of onychopapilloma |
title_sort | expression patterns of hair-related keratins and epithelial keratins in onychopapilloma: the significance of clarifying the origin of onychopapilloma |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722942/ https://www.ncbi.nlm.nih.gov/pubmed/36482914 http://dx.doi.org/10.3389/fmed.2022.1059624 |
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