Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity

CYP46A1 is a brain-specific enzyme responsible for cholesterol homeostasis. Inhibition of CYP46A1 activity serves as a therapeutic target for excitatory neurotoxicity. Sesame is a common medicine and food resource; its component lignans possess various pharmacological activities. In this study, the...

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Detalles Bibliográficos
Autores principales: Du, Jie, Chen, Xiaodong, Zhao, Yongshun, Zhao, Tingting, Wang, Dalong, Chen, Zujia, Wang, Changyuan, Meng, Qiang, Yao, Jialin, Sun, Huijun, Liu, Kexin, Wu, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722955/
https://www.ncbi.nlm.nih.gov/pubmed/36483743
http://dx.doi.org/10.3389/fphar.2022.1046814

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