Clinical and Translational Advances in Glioma Immunotherapy

Gliomas are highly treatment refractory against immune checkpoint blockade, an immunotherapeutic modality that revolutionized therapy for many tumors. At the same time, technological innovation has dramatically accelerated the development of immunotherapeutic approaches such as personalized tumor-sp...

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Autores principales: Bunse, Lukas, Bunse, Theresa, Krämer, Christopher, Chih, Yu-Chan, Platten, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723056/
https://www.ncbi.nlm.nih.gov/pubmed/36303101
http://dx.doi.org/10.1007/s13311-022-01313-9
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author Bunse, Lukas
Bunse, Theresa
Krämer, Christopher
Chih, Yu-Chan
Platten, Michael
author_facet Bunse, Lukas
Bunse, Theresa
Krämer, Christopher
Chih, Yu-Chan
Platten, Michael
author_sort Bunse, Lukas
collection PubMed
description Gliomas are highly treatment refractory against immune checkpoint blockade, an immunotherapeutic modality that revolutionized therapy for many tumors. At the same time, technological innovation has dramatically accelerated the development of immunotherapeutic approaches such as personalized tumor-specific vaccine production, dendritic cell vaccine manufacture, patient-individual target selection and chimeric antigen receptor, and T cell receptor T cell manufacture. Here we review recent clinical and translational advances in glioma immunotherapy with a focus on targets and their cognate immune receptor derivates as well as concepts to improve intratumoral T cell effector functions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13311-022-01313-9.
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spelling pubmed-97230562022-12-07 Clinical and Translational Advances in Glioma Immunotherapy Bunse, Lukas Bunse, Theresa Krämer, Christopher Chih, Yu-Chan Platten, Michael Neurotherapeutics Review Gliomas are highly treatment refractory against immune checkpoint blockade, an immunotherapeutic modality that revolutionized therapy for many tumors. At the same time, technological innovation has dramatically accelerated the development of immunotherapeutic approaches such as personalized tumor-specific vaccine production, dendritic cell vaccine manufacture, patient-individual target selection and chimeric antigen receptor, and T cell receptor T cell manufacture. Here we review recent clinical and translational advances in glioma immunotherapy with a focus on targets and their cognate immune receptor derivates as well as concepts to improve intratumoral T cell effector functions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13311-022-01313-9. Springer International Publishing 2022-10-27 2022-10 /pmc/articles/PMC9723056/ /pubmed/36303101 http://dx.doi.org/10.1007/s13311-022-01313-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Bunse, Lukas
Bunse, Theresa
Krämer, Christopher
Chih, Yu-Chan
Platten, Michael
Clinical and Translational Advances in Glioma Immunotherapy
title Clinical and Translational Advances in Glioma Immunotherapy
title_full Clinical and Translational Advances in Glioma Immunotherapy
title_fullStr Clinical and Translational Advances in Glioma Immunotherapy
title_full_unstemmed Clinical and Translational Advances in Glioma Immunotherapy
title_short Clinical and Translational Advances in Glioma Immunotherapy
title_sort clinical and translational advances in glioma immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723056/
https://www.ncbi.nlm.nih.gov/pubmed/36303101
http://dx.doi.org/10.1007/s13311-022-01313-9
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