FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM

Doxorubicin (DOX) is an effective anthracycline chemotherapeutic anticancer drug with its life-threatening cardiotoxicity severely limiting its clinical application. Mitochondrial damage-induced cardiomyocyte death is considered an essential cue for DOX cardiotoxicity. FUN14 domain containing 1 (FUN...

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Detalles Bibliográficos
Autores principales: Bi, Yaguang, Xu, Haixia, Wang, Xiang, Zhu, Hong, Ge, Junbo, Ren, Jun, Zhang, Yingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723119/
https://www.ncbi.nlm.nih.gov/pubmed/36470869
http://dx.doi.org/10.1038/s41419-022-05460-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723119/
https://www.ncbi.nlm.nih.gov/pubmed/36470869
http://dx.doi.org/10.1038/s41419-022-05460-x

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