SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice

The vitamin-C-synthesizing enzyme senescent marker protein 30 (SMP30) is a cold resistance gene in Drosophila, and vitamin C concentration increases in brown adipose tissue post-cold exposure. However, the roles of SMP30 in thermogenesis are unknown. Here, we tested the molecular mechanism of thermo...

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Detalles Bibliográficos
Autores principales: Lee, Bonggi, An, Hye Jin, Kim, Dae Hyun, Lee, Min-Kyeong, Jeong, Hyeon Hak, Chung, Ki Wung, Go, Younghoon, Seo, Arnold Y., Kim, Il Yong, Seong, Je Kyung, Yu, Byung Pal, Lee, Jaewon, Im, Eunok, Lee, In-Kyu, Lee, Myung-Shik, Yamada, Ken-ichi, Chung, Hae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723126/
https://www.ncbi.nlm.nih.gov/pubmed/36434042
http://dx.doi.org/10.1038/s12276-022-00888-9

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