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Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis
PURPOSE: The study characterizes regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in abnormal regions of brain in patients of chronic kidney disease (CKD). MATERIALS AND METHODS: A total of 64 patients of CKD were divided into 26 cases of non-dialysis-dependent chronic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723135/ https://www.ncbi.nlm.nih.gov/pubmed/36483180 http://dx.doi.org/10.3389/fnins.2022.1064813 |
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author | Yu, Huan Zhang, Chaoyang Cai, Yan Wu, Ning Duan, Kai Bo, Wenwei Liu, Ying Xu, Zitong |
author_facet | Yu, Huan Zhang, Chaoyang Cai, Yan Wu, Ning Duan, Kai Bo, Wenwei Liu, Ying Xu, Zitong |
author_sort | Yu, Huan |
collection | PubMed |
description | PURPOSE: The study characterizes regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in abnormal regions of brain in patients of chronic kidney disease (CKD). MATERIALS AND METHODS: A total of 64 patients of CKD were divided into 26 cases of non-dialysis-dependent chronic kidney disease (NDD-CKD), and 38 cases of dialysis-dependent chronic kidney disease (DD-CKD). A total of 43 healthy controls (normal control, NC) were also included. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI). ALFF and ReHo data was processed for monitoring the differences in spontaneous brain activity between the three groups. ALFF and ReHo values of extracted differential brain regions were correlated to the clinical data and cognitive scores of CKD patients. RESULTS: Non-dialysis-dependent group has increased ALFF levels in 13 brain regions while that of DD group in 28 brain regions as compared with NC group. ReHo values are altered in six brain regions of DD group. ALFF is correlated with urea nitrogen and ReHo with urea nitrogen and creatinine. DD group has altered ReHo in two brain regions compared with NDD group. The differences are located in basal ganglia, cerebellar, and hippocampus regions. CONCLUSION: Abnormal activity in basal ganglia, cerebellar, and hippocampal regions may be involved in the cognitive decline of CKD patients. This link can provide theoretical basis for understanding the cognitive decline. |
format | Online Article Text |
id | pubmed-9723135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97231352022-12-07 Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis Yu, Huan Zhang, Chaoyang Cai, Yan Wu, Ning Duan, Kai Bo, Wenwei Liu, Ying Xu, Zitong Front Neurosci Neuroscience PURPOSE: The study characterizes regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in abnormal regions of brain in patients of chronic kidney disease (CKD). MATERIALS AND METHODS: A total of 64 patients of CKD were divided into 26 cases of non-dialysis-dependent chronic kidney disease (NDD-CKD), and 38 cases of dialysis-dependent chronic kidney disease (DD-CKD). A total of 43 healthy controls (normal control, NC) were also included. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI). ALFF and ReHo data was processed for monitoring the differences in spontaneous brain activity between the three groups. ALFF and ReHo values of extracted differential brain regions were correlated to the clinical data and cognitive scores of CKD patients. RESULTS: Non-dialysis-dependent group has increased ALFF levels in 13 brain regions while that of DD group in 28 brain regions as compared with NC group. ReHo values are altered in six brain regions of DD group. ALFF is correlated with urea nitrogen and ReHo with urea nitrogen and creatinine. DD group has altered ReHo in two brain regions compared with NDD group. The differences are located in basal ganglia, cerebellar, and hippocampus regions. CONCLUSION: Abnormal activity in basal ganglia, cerebellar, and hippocampal regions may be involved in the cognitive decline of CKD patients. This link can provide theoretical basis for understanding the cognitive decline. Frontiers Media S.A. 2022-11-22 /pmc/articles/PMC9723135/ /pubmed/36483180 http://dx.doi.org/10.3389/fnins.2022.1064813 Text en Copyright © 2022 Yu, Zhang, Cai, Wu, Duan, Bo, Liu and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Yu, Huan Zhang, Chaoyang Cai, Yan Wu, Ning Duan, Kai Bo, Wenwei Liu, Ying Xu, Zitong Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis |
title | Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis |
title_full | Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis |
title_fullStr | Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis |
title_full_unstemmed | Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis |
title_short | Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis |
title_sort | abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723135/ https://www.ncbi.nlm.nih.gov/pubmed/36483180 http://dx.doi.org/10.3389/fnins.2022.1064813 |
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