Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model

Understanding how Baijiu facilitates blood circulation and prevents blood stasis is crucial for revealing the mechanism of Baijiu for cardiovascular disease (CVD) risk reduction. Here we established a zebrafish thrombosis model induced using arachidonic acid (AA) to quantitatively evaluate the antit...

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Autores principales: Zhu, Hui, Lan, Chaohua, Zhao, Dong, Wang, Ning, Du, Di, Luo, Huibo, Lu, Huiqiang, Peng, Zhifu, Wang, Yumeng, Qiao, Zongwei, Huang, Yong, Sun, Baoguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723178/
https://www.ncbi.nlm.nih.gov/pubmed/36470888
http://dx.doi.org/10.1038/s41538-022-00170-2
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author Zhu, Hui
Lan, Chaohua
Zhao, Dong
Wang, Ning
Du, Di
Luo, Huibo
Lu, Huiqiang
Peng, Zhifu
Wang, Yumeng
Qiao, Zongwei
Huang, Yong
Sun, Baoguo
author_facet Zhu, Hui
Lan, Chaohua
Zhao, Dong
Wang, Ning
Du, Di
Luo, Huibo
Lu, Huiqiang
Peng, Zhifu
Wang, Yumeng
Qiao, Zongwei
Huang, Yong
Sun, Baoguo
author_sort Zhu, Hui
collection PubMed
description Understanding how Baijiu facilitates blood circulation and prevents blood stasis is crucial for revealing the mechanism of Baijiu for cardiovascular disease (CVD) risk reduction. Here we established a zebrafish thrombosis model induced using arachidonic acid (AA) to quantitatively evaluate the antithrombotic effect of Wuliangye Baijiu. The prevention and reduction effects of aspirin, Wuliangye, and ethanol on thrombosis were compared using imaging and molecular characterization. Wuliangye Baijiu reduces thrombotic risks and oxidative stress in the AA-treated zebrafish, while ethanol with the same concentration has no similar effect. The prevention and reduction effects of Wuliangye on thrombosis are attributed to the change in the metabolic and signaling pathways related to platelet aggregation and adhesion, oxidative stress and inflammatory response.
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spelling pubmed-97231782022-12-07 Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model Zhu, Hui Lan, Chaohua Zhao, Dong Wang, Ning Du, Di Luo, Huibo Lu, Huiqiang Peng, Zhifu Wang, Yumeng Qiao, Zongwei Huang, Yong Sun, Baoguo NPJ Sci Food Article Understanding how Baijiu facilitates blood circulation and prevents blood stasis is crucial for revealing the mechanism of Baijiu for cardiovascular disease (CVD) risk reduction. Here we established a zebrafish thrombosis model induced using arachidonic acid (AA) to quantitatively evaluate the antithrombotic effect of Wuliangye Baijiu. The prevention and reduction effects of aspirin, Wuliangye, and ethanol on thrombosis were compared using imaging and molecular characterization. Wuliangye Baijiu reduces thrombotic risks and oxidative stress in the AA-treated zebrafish, while ethanol with the same concentration has no similar effect. The prevention and reduction effects of Wuliangye on thrombosis are attributed to the change in the metabolic and signaling pathways related to platelet aggregation and adhesion, oxidative stress and inflammatory response. Nature Publishing Group UK 2022-12-05 /pmc/articles/PMC9723178/ /pubmed/36470888 http://dx.doi.org/10.1038/s41538-022-00170-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhu, Hui
Lan, Chaohua
Zhao, Dong
Wang, Ning
Du, Di
Luo, Huibo
Lu, Huiqiang
Peng, Zhifu
Wang, Yumeng
Qiao, Zongwei
Huang, Yong
Sun, Baoguo
Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model
title Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model
title_full Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model
title_fullStr Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model
title_full_unstemmed Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model
title_short Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model
title_sort wuliangye baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723178/
https://www.ncbi.nlm.nih.gov/pubmed/36470888
http://dx.doi.org/10.1038/s41538-022-00170-2
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