Single-cell analysis of multiple myelomas refines the molecular features of bortezomib treatment responsiveness

Both the tumor and tumor microenvironment (TME) are crucial for pathogenesis and chemotherapy resistance in multiple myeloma (MM). Bortezomib, commonly used for MM treatment, works on both MM and TME cells, but innate and acquired resistance easily develop. By single-cell RNA sequencing (scRNA-seq),...

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Detalles Bibliográficos
Autores principales: Jung, Seung-Hyun, Park, Sung-Soo, Lim, Ji-Young, Sohn, Seon Yong, Kim, Na Yung, Kim, Dokyeong, Lee, Sug Hyung, Chung, Yeun-Jun, Min, Chang-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723182/
https://www.ncbi.nlm.nih.gov/pubmed/36380017
http://dx.doi.org/10.1038/s12276-022-00884-z

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