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Novel inflammatory biomarkers in thyroid eye disease
PURPOSE: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves’ disease (GD). METHODS: Patients with GD (n = 100, 77 females) were included from the National Norwegian Registry of Organ-Sp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723260/ https://www.ncbi.nlm.nih.gov/pubmed/35675127 http://dx.doi.org/10.1530/EJE-22-0247 |
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author | Ueland, Hans Olav Ueland, Grethe Åstrøm Løvås, Kristian Breivk, Lars Ertesvåg Thrane, Alexander Stanley Meling Stokland, Ann-Elin Rødahl, Eyvind Husebye, Eystein Sverre |
author_facet | Ueland, Hans Olav Ueland, Grethe Åstrøm Løvås, Kristian Breivk, Lars Ertesvåg Thrane, Alexander Stanley Meling Stokland, Ann-Elin Rødahl, Eyvind Husebye, Eystein Sverre |
author_sort | Ueland, Hans Olav |
collection | PubMed |
description | PURPOSE: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves’ disease (GD). METHODS: Patients with GD (n = 100, 77 females) were included from the National Norwegian Registry of Organ-Specific Diseases. Serum samples were analysed for 92 different inflammatory biomarkers using the proximity extension assay. Biomarker levels were compared between groups of patients with and without TED and healthy subjects (HS) (n = 120). RESULTS: TED was found in 36 of 100 GD patients. Significant (P < 0.05) differences in the levels of 52 inflammatory biomarkers were found when GD patients and HS were compared (42 elevated and 10 decreased). Out of the 42 elevated biomarkers, a significantly higher serum level of interleukin-6 (IL6) (P = 0.022) and macrophage colony-stimulating factor (CSF1) (P = 0.015) were found in patients with TED compared to patients without TED. Patients with severe TED also had significantly elevated levels of Fms-related tyrosine kinase 3 ligand (FLT3LG) (P = 0.009). Furthermore, fibroblast growth factor 21 (FGF21) was significantly increased (P = 0.008) in patients with GD who had no signs of TED at baseline but developed TED later. CONCLUSION: We demonstrate an immunologic fingerprint of GD, as serum levels of several inflammation-related proteins were elevated, while others were decreased. Distinctly increased levels of IL6, CSF1, FLT3LG, and FGF21 were observed in TED, suggesting that these inflammatory proteins could be important in the pathogenesis, and therefore potential new biomarkers for clinical use. |
format | Online Article Text |
id | pubmed-9723260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-97232602022-12-06 Novel inflammatory biomarkers in thyroid eye disease Ueland, Hans Olav Ueland, Grethe Åstrøm Løvås, Kristian Breivk, Lars Ertesvåg Thrane, Alexander Stanley Meling Stokland, Ann-Elin Rødahl, Eyvind Husebye, Eystein Sverre Eur J Endocrinol Original Research PURPOSE: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves’ disease (GD). METHODS: Patients with GD (n = 100, 77 females) were included from the National Norwegian Registry of Organ-Specific Diseases. Serum samples were analysed for 92 different inflammatory biomarkers using the proximity extension assay. Biomarker levels were compared between groups of patients with and without TED and healthy subjects (HS) (n = 120). RESULTS: TED was found in 36 of 100 GD patients. Significant (P < 0.05) differences in the levels of 52 inflammatory biomarkers were found when GD patients and HS were compared (42 elevated and 10 decreased). Out of the 42 elevated biomarkers, a significantly higher serum level of interleukin-6 (IL6) (P = 0.022) and macrophage colony-stimulating factor (CSF1) (P = 0.015) were found in patients with TED compared to patients without TED. Patients with severe TED also had significantly elevated levels of Fms-related tyrosine kinase 3 ligand (FLT3LG) (P = 0.009). Furthermore, fibroblast growth factor 21 (FGF21) was significantly increased (P = 0.008) in patients with GD who had no signs of TED at baseline but developed TED later. CONCLUSION: We demonstrate an immunologic fingerprint of GD, as serum levels of several inflammation-related proteins were elevated, while others were decreased. Distinctly increased levels of IL6, CSF1, FLT3LG, and FGF21 were observed in TED, suggesting that these inflammatory proteins could be important in the pathogenesis, and therefore potential new biomarkers for clinical use. Bioscientifica Ltd 2022-06-08 /pmc/articles/PMC9723260/ /pubmed/35675127 http://dx.doi.org/10.1530/EJE-22-0247 Text en © The authors https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Original Research Ueland, Hans Olav Ueland, Grethe Åstrøm Løvås, Kristian Breivk, Lars Ertesvåg Thrane, Alexander Stanley Meling Stokland, Ann-Elin Rødahl, Eyvind Husebye, Eystein Sverre Novel inflammatory biomarkers in thyroid eye disease |
title | Novel inflammatory biomarkers in thyroid eye disease |
title_full | Novel inflammatory biomarkers in thyroid eye disease |
title_fullStr | Novel inflammatory biomarkers in thyroid eye disease |
title_full_unstemmed | Novel inflammatory biomarkers in thyroid eye disease |
title_short | Novel inflammatory biomarkers in thyroid eye disease |
title_sort | novel inflammatory biomarkers in thyroid eye disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723260/ https://www.ncbi.nlm.nih.gov/pubmed/35675127 http://dx.doi.org/10.1530/EJE-22-0247 |
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