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Novel inflammatory biomarkers in thyroid eye disease

PURPOSE: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves’ disease (GD). METHODS: Patients with GD (n = 100, 77 females) were included from the National Norwegian Registry of Organ-Sp...

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Autores principales: Ueland, Hans Olav, Ueland, Grethe Åstrøm, Løvås, Kristian, Breivk, Lars Ertesvåg, Thrane, Alexander Stanley, Meling Stokland, Ann-Elin, Rødahl, Eyvind, Husebye, Eystein Sverre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723260/
https://www.ncbi.nlm.nih.gov/pubmed/35675127
http://dx.doi.org/10.1530/EJE-22-0247
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author Ueland, Hans Olav
Ueland, Grethe Åstrøm
Løvås, Kristian
Breivk, Lars Ertesvåg
Thrane, Alexander Stanley
Meling Stokland, Ann-Elin
Rødahl, Eyvind
Husebye, Eystein Sverre
author_facet Ueland, Hans Olav
Ueland, Grethe Åstrøm
Løvås, Kristian
Breivk, Lars Ertesvåg
Thrane, Alexander Stanley
Meling Stokland, Ann-Elin
Rødahl, Eyvind
Husebye, Eystein Sverre
author_sort Ueland, Hans Olav
collection PubMed
description PURPOSE: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves’ disease (GD). METHODS: Patients with GD (n = 100, 77 females) were included from the National Norwegian Registry of Organ-Specific Diseases. Serum samples were analysed for 92 different inflammatory biomarkers using the proximity extension assay. Biomarker levels were compared between groups of patients with and without TED and healthy subjects (HS) (n = 120). RESULTS: TED was found in 36 of 100 GD patients. Significant (P < 0.05) differences in the levels of 52 inflammatory biomarkers were found when GD patients and HS were compared (42 elevated and 10 decreased). Out of the 42 elevated biomarkers, a significantly higher serum level of interleukin-6 (IL6) (P = 0.022) and macrophage colony-stimulating factor (CSF1) (P = 0.015) were found in patients with TED compared to patients without TED. Patients with severe TED also had significantly elevated levels of Fms-related tyrosine kinase 3 ligand (FLT3LG) (P = 0.009). Furthermore, fibroblast growth factor 21 (FGF21) was significantly increased (P = 0.008) in patients with GD who had no signs of TED at baseline but developed TED later. CONCLUSION: We demonstrate an immunologic fingerprint of GD, as serum levels of several inflammation-related proteins were elevated, while others were decreased. Distinctly increased levels of IL6, CSF1, FLT3LG, and FGF21 were observed in TED, suggesting that these inflammatory proteins could be important in the pathogenesis, and therefore potential new biomarkers for clinical use.
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spelling pubmed-97232602022-12-06 Novel inflammatory biomarkers in thyroid eye disease Ueland, Hans Olav Ueland, Grethe Åstrøm Løvås, Kristian Breivk, Lars Ertesvåg Thrane, Alexander Stanley Meling Stokland, Ann-Elin Rødahl, Eyvind Husebye, Eystein Sverre Eur J Endocrinol Original Research PURPOSE: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves’ disease (GD). METHODS: Patients with GD (n = 100, 77 females) were included from the National Norwegian Registry of Organ-Specific Diseases. Serum samples were analysed for 92 different inflammatory biomarkers using the proximity extension assay. Biomarker levels were compared between groups of patients with and without TED and healthy subjects (HS) (n = 120). RESULTS: TED was found in 36 of 100 GD patients. Significant (P < 0.05) differences in the levels of 52 inflammatory biomarkers were found when GD patients and HS were compared (42 elevated and 10 decreased). Out of the 42 elevated biomarkers, a significantly higher serum level of interleukin-6 (IL6) (P = 0.022) and macrophage colony-stimulating factor (CSF1) (P = 0.015) were found in patients with TED compared to patients without TED. Patients with severe TED also had significantly elevated levels of Fms-related tyrosine kinase 3 ligand (FLT3LG) (P = 0.009). Furthermore, fibroblast growth factor 21 (FGF21) was significantly increased (P = 0.008) in patients with GD who had no signs of TED at baseline but developed TED later. CONCLUSION: We demonstrate an immunologic fingerprint of GD, as serum levels of several inflammation-related proteins were elevated, while others were decreased. Distinctly increased levels of IL6, CSF1, FLT3LG, and FGF21 were observed in TED, suggesting that these inflammatory proteins could be important in the pathogenesis, and therefore potential new biomarkers for clinical use. Bioscientifica Ltd 2022-06-08 /pmc/articles/PMC9723260/ /pubmed/35675127 http://dx.doi.org/10.1530/EJE-22-0247 Text en © The authors https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Research
Ueland, Hans Olav
Ueland, Grethe Åstrøm
Løvås, Kristian
Breivk, Lars Ertesvåg
Thrane, Alexander Stanley
Meling Stokland, Ann-Elin
Rødahl, Eyvind
Husebye, Eystein Sverre
Novel inflammatory biomarkers in thyroid eye disease
title Novel inflammatory biomarkers in thyroid eye disease
title_full Novel inflammatory biomarkers in thyroid eye disease
title_fullStr Novel inflammatory biomarkers in thyroid eye disease
title_full_unstemmed Novel inflammatory biomarkers in thyroid eye disease
title_short Novel inflammatory biomarkers in thyroid eye disease
title_sort novel inflammatory biomarkers in thyroid eye disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723260/
https://www.ncbi.nlm.nih.gov/pubmed/35675127
http://dx.doi.org/10.1530/EJE-22-0247
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