Cargando…

The potential impact of melanosomal pH and metabolism on melanoma

Melanin is synthesized in melanocytes and is transferred into keratinocytes to block the effects of ultraviolet (UV) radiation and is important for preventing skin cancers including melanoma. However, it is known that after melanomagenesis and melanoma invasion or metastases, melanin synthesis still...

Descripción completa

Detalles Bibliográficos
Autores principales: You, Jaewon, Yusupova, Maftuna, Zippin, Jonathan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723380/
https://www.ncbi.nlm.nih.gov/pubmed/36483028
http://dx.doi.org/10.3389/fonc.2022.887770
_version_ 1784844162150957056
author You, Jaewon
Yusupova, Maftuna
Zippin, Jonathan H.
author_facet You, Jaewon
Yusupova, Maftuna
Zippin, Jonathan H.
author_sort You, Jaewon
collection PubMed
description Melanin is synthesized in melanocytes and is transferred into keratinocytes to block the effects of ultraviolet (UV) radiation and is important for preventing skin cancers including melanoma. However, it is known that after melanomagenesis and melanoma invasion or metastases, melanin synthesis still occurs. Since melanoma cells are no longer involved in the sun tanning process, it is unclear why melanocytes would maintain melanin synthesis after melanomagenesis has occurred. Aside from blocking UV-induced DNA mutation, melanin may provide other metabolic functions that could benefit melanoma. In addition, studies have suggested that there may be a selective advantage to melanin synthesis in melanoma; however, mechanisms regulating melanin synthesis outside the epidermis or hair follicle is unknown. We will discuss how melanosomal pH controls melanin synthesis in melanocytes and how melanosomal pH control of melanin synthesis might function in melanoma. We will also discuss potential reasons why melanin synthesis might be beneficial for melanoma cellular metabolism and provide a rationale for why melanin synthesis is not limited to benign melanocytes.
format Online
Article
Text
id pubmed-9723380
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97233802022-12-07 The potential impact of melanosomal pH and metabolism on melanoma You, Jaewon Yusupova, Maftuna Zippin, Jonathan H. Front Oncol Oncology Melanin is synthesized in melanocytes and is transferred into keratinocytes to block the effects of ultraviolet (UV) radiation and is important for preventing skin cancers including melanoma. However, it is known that after melanomagenesis and melanoma invasion or metastases, melanin synthesis still occurs. Since melanoma cells are no longer involved in the sun tanning process, it is unclear why melanocytes would maintain melanin synthesis after melanomagenesis has occurred. Aside from blocking UV-induced DNA mutation, melanin may provide other metabolic functions that could benefit melanoma. In addition, studies have suggested that there may be a selective advantage to melanin synthesis in melanoma; however, mechanisms regulating melanin synthesis outside the epidermis or hair follicle is unknown. We will discuss how melanosomal pH controls melanin synthesis in melanocytes and how melanosomal pH control of melanin synthesis might function in melanoma. We will also discuss potential reasons why melanin synthesis might be beneficial for melanoma cellular metabolism and provide a rationale for why melanin synthesis is not limited to benign melanocytes. Frontiers Media S.A. 2022-11-22 /pmc/articles/PMC9723380/ /pubmed/36483028 http://dx.doi.org/10.3389/fonc.2022.887770 Text en Copyright © 2022 You, Yusupova and Zippin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
You, Jaewon
Yusupova, Maftuna
Zippin, Jonathan H.
The potential impact of melanosomal pH and metabolism on melanoma
title The potential impact of melanosomal pH and metabolism on melanoma
title_full The potential impact of melanosomal pH and metabolism on melanoma
title_fullStr The potential impact of melanosomal pH and metabolism on melanoma
title_full_unstemmed The potential impact of melanosomal pH and metabolism on melanoma
title_short The potential impact of melanosomal pH and metabolism on melanoma
title_sort potential impact of melanosomal ph and metabolism on melanoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723380/
https://www.ncbi.nlm.nih.gov/pubmed/36483028
http://dx.doi.org/10.3389/fonc.2022.887770
work_keys_str_mv AT youjaewon thepotentialimpactofmelanosomalphandmetabolismonmelanoma
AT yusupovamaftuna thepotentialimpactofmelanosomalphandmetabolismonmelanoma
AT zippinjonathanh thepotentialimpactofmelanosomalphandmetabolismonmelanoma
AT youjaewon potentialimpactofmelanosomalphandmetabolismonmelanoma
AT yusupovamaftuna potentialimpactofmelanosomalphandmetabolismonmelanoma
AT zippinjonathanh potentialimpactofmelanosomalphandmetabolismonmelanoma