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The potential impact of melanosomal pH and metabolism on melanoma
Melanin is synthesized in melanocytes and is transferred into keratinocytes to block the effects of ultraviolet (UV) radiation and is important for preventing skin cancers including melanoma. However, it is known that after melanomagenesis and melanoma invasion or metastases, melanin synthesis still...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723380/ https://www.ncbi.nlm.nih.gov/pubmed/36483028 http://dx.doi.org/10.3389/fonc.2022.887770 |
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author | You, Jaewon Yusupova, Maftuna Zippin, Jonathan H. |
author_facet | You, Jaewon Yusupova, Maftuna Zippin, Jonathan H. |
author_sort | You, Jaewon |
collection | PubMed |
description | Melanin is synthesized in melanocytes and is transferred into keratinocytes to block the effects of ultraviolet (UV) radiation and is important for preventing skin cancers including melanoma. However, it is known that after melanomagenesis and melanoma invasion or metastases, melanin synthesis still occurs. Since melanoma cells are no longer involved in the sun tanning process, it is unclear why melanocytes would maintain melanin synthesis after melanomagenesis has occurred. Aside from blocking UV-induced DNA mutation, melanin may provide other metabolic functions that could benefit melanoma. In addition, studies have suggested that there may be a selective advantage to melanin synthesis in melanoma; however, mechanisms regulating melanin synthesis outside the epidermis or hair follicle is unknown. We will discuss how melanosomal pH controls melanin synthesis in melanocytes and how melanosomal pH control of melanin synthesis might function in melanoma. We will also discuss potential reasons why melanin synthesis might be beneficial for melanoma cellular metabolism and provide a rationale for why melanin synthesis is not limited to benign melanocytes. |
format | Online Article Text |
id | pubmed-9723380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97233802022-12-07 The potential impact of melanosomal pH and metabolism on melanoma You, Jaewon Yusupova, Maftuna Zippin, Jonathan H. Front Oncol Oncology Melanin is synthesized in melanocytes and is transferred into keratinocytes to block the effects of ultraviolet (UV) radiation and is important for preventing skin cancers including melanoma. However, it is known that after melanomagenesis and melanoma invasion or metastases, melanin synthesis still occurs. Since melanoma cells are no longer involved in the sun tanning process, it is unclear why melanocytes would maintain melanin synthesis after melanomagenesis has occurred. Aside from blocking UV-induced DNA mutation, melanin may provide other metabolic functions that could benefit melanoma. In addition, studies have suggested that there may be a selective advantage to melanin synthesis in melanoma; however, mechanisms regulating melanin synthesis outside the epidermis or hair follicle is unknown. We will discuss how melanosomal pH controls melanin synthesis in melanocytes and how melanosomal pH control of melanin synthesis might function in melanoma. We will also discuss potential reasons why melanin synthesis might be beneficial for melanoma cellular metabolism and provide a rationale for why melanin synthesis is not limited to benign melanocytes. Frontiers Media S.A. 2022-11-22 /pmc/articles/PMC9723380/ /pubmed/36483028 http://dx.doi.org/10.3389/fonc.2022.887770 Text en Copyright © 2022 You, Yusupova and Zippin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology You, Jaewon Yusupova, Maftuna Zippin, Jonathan H. The potential impact of melanosomal pH and metabolism on melanoma |
title | The potential impact of melanosomal pH and metabolism on melanoma |
title_full | The potential impact of melanosomal pH and metabolism on melanoma |
title_fullStr | The potential impact of melanosomal pH and metabolism on melanoma |
title_full_unstemmed | The potential impact of melanosomal pH and metabolism on melanoma |
title_short | The potential impact of melanosomal pH and metabolism on melanoma |
title_sort | potential impact of melanosomal ph and metabolism on melanoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723380/ https://www.ncbi.nlm.nih.gov/pubmed/36483028 http://dx.doi.org/10.3389/fonc.2022.887770 |
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