Mechanism of curaxin-dependent nucleosome unfolding by FACT

Human FACT (FACT) is a multifunctional histone chaperone involved in transcription, replication and DNA repair. Curaxins are anticancer compounds that induce FACT-dependent nucleosome unfolding and trapping of FACT in the chromatin of cancer cells (c-trapping) through an unknown molecular mechanism....

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Detalles Bibliográficos
Autores principales: Volokh, Olesya I., Sivkina, Anastasia L., Moiseenko, Andrey V., Popinako, Anna V., Karlova, Maria G., Valieva, Maria E., Kotova, Elena Y., Kirpichnikov, Mikhail P., Formosa, Timothy, Studitsky, Vasily M., Sokolova, Olga S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723464/
https://www.ncbi.nlm.nih.gov/pubmed/36483541
http://dx.doi.org/10.3389/fmolb.2022.1048117

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