Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

During force-generating steps of the muscle crossbridge cycle, the tip of the myosin motor, specifically loop-4, contacts the tropomyosin cable of actin filaments. In the current study, we determined the corresponding effect of myosin loop-4 on the regulatory positioning of tropomyosin on actin. To...

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Detalles Bibliográficos
Autores principales: Doran, Matthew H., Rynkiewicz, Michael J., Pavadai, Elumalai, Bodt, Skylar M.L., Rasicci, David, Moore, Jeffrey R., Yengo, Christopher M., Bullitt, Esther, Lehman, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723511/
https://www.ncbi.nlm.nih.gov/pubmed/36459134
http://dx.doi.org/10.1085/jgp.202213274

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