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Ion channel regulation of gut immunity
Mounting evidence indicates that gastrointestinal (GI) homeostasis hinges on communications among many cellular networks including the intestinal epithelium, the immune system, and both intrinsic and extrinsic nerves innervating the gut. The GI tract, especially the colon, is the home base for gut m...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723512/ https://www.ncbi.nlm.nih.gov/pubmed/36459135 http://dx.doi.org/10.1085/jgp.202113042 |
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author | Feng, Jing Xie, Zili Hu, Hongzhen |
author_facet | Feng, Jing Xie, Zili Hu, Hongzhen |
author_sort | Feng, Jing |
collection | PubMed |
description | Mounting evidence indicates that gastrointestinal (GI) homeostasis hinges on communications among many cellular networks including the intestinal epithelium, the immune system, and both intrinsic and extrinsic nerves innervating the gut. The GI tract, especially the colon, is the home base for gut microbiome which dynamically regulates immune function. The gut’s immune system also provides an effective defense against harmful pathogens entering the GI tract while maintaining immune homeostasis to avoid exaggerated immune reaction to innocuous food and commensal antigens which are important causes of inflammatory disorders such as coeliac disease and inflammatory bowel diseases (IBD). Various ion channels have been detected in multiple cell types throughout the GI tract. By regulating membrane properties and intracellular biochemical signaling, ion channels play a critical role in synchronized signaling among diverse cellular components in the gut that orchestrates the GI immune response. This work focuses on the role of ion channels in immune cells, non-immune resident cells, and neuroimmune interactions in the gut at the steady state and pathological conditions. Understanding the cellular and molecular basis of ion channel signaling in these immune-related pathways and initial testing of pharmacological intervention will facilitate the development of ion channel–based therapeutic approaches for the treatment of intestinal inflammation. |
format | Online Article Text |
id | pubmed-9723512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97235122022-12-07 Ion channel regulation of gut immunity Feng, Jing Xie, Zili Hu, Hongzhen J Gen Physiol Review Mounting evidence indicates that gastrointestinal (GI) homeostasis hinges on communications among many cellular networks including the intestinal epithelium, the immune system, and both intrinsic and extrinsic nerves innervating the gut. The GI tract, especially the colon, is the home base for gut microbiome which dynamically regulates immune function. The gut’s immune system also provides an effective defense against harmful pathogens entering the GI tract while maintaining immune homeostasis to avoid exaggerated immune reaction to innocuous food and commensal antigens which are important causes of inflammatory disorders such as coeliac disease and inflammatory bowel diseases (IBD). Various ion channels have been detected in multiple cell types throughout the GI tract. By regulating membrane properties and intracellular biochemical signaling, ion channels play a critical role in synchronized signaling among diverse cellular components in the gut that orchestrates the GI immune response. This work focuses on the role of ion channels in immune cells, non-immune resident cells, and neuroimmune interactions in the gut at the steady state and pathological conditions. Understanding the cellular and molecular basis of ion channel signaling in these immune-related pathways and initial testing of pharmacological intervention will facilitate the development of ion channel–based therapeutic approaches for the treatment of intestinal inflammation. Rockefeller University Press 2022-12-02 /pmc/articles/PMC9723512/ /pubmed/36459135 http://dx.doi.org/10.1085/jgp.202113042 Text en © 2022 Feng et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Feng, Jing Xie, Zili Hu, Hongzhen Ion channel regulation of gut immunity |
title | Ion channel regulation of gut immunity |
title_full | Ion channel regulation of gut immunity |
title_fullStr | Ion channel regulation of gut immunity |
title_full_unstemmed | Ion channel regulation of gut immunity |
title_short | Ion channel regulation of gut immunity |
title_sort | ion channel regulation of gut immunity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723512/ https://www.ncbi.nlm.nih.gov/pubmed/36459135 http://dx.doi.org/10.1085/jgp.202113042 |
work_keys_str_mv | AT fengjing ionchannelregulationofgutimmunity AT xiezili ionchannelregulationofgutimmunity AT huhongzhen ionchannelregulationofgutimmunity |