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Ion channel regulation of gut immunity

Mounting evidence indicates that gastrointestinal (GI) homeostasis hinges on communications among many cellular networks including the intestinal epithelium, the immune system, and both intrinsic and extrinsic nerves innervating the gut. The GI tract, especially the colon, is the home base for gut m...

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Detalles Bibliográficos
Autores principales: Feng, Jing, Xie, Zili, Hu, Hongzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723512/
https://www.ncbi.nlm.nih.gov/pubmed/36459135
http://dx.doi.org/10.1085/jgp.202113042
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author Feng, Jing
Xie, Zili
Hu, Hongzhen
author_facet Feng, Jing
Xie, Zili
Hu, Hongzhen
author_sort Feng, Jing
collection PubMed
description Mounting evidence indicates that gastrointestinal (GI) homeostasis hinges on communications among many cellular networks including the intestinal epithelium, the immune system, and both intrinsic and extrinsic nerves innervating the gut. The GI tract, especially the colon, is the home base for gut microbiome which dynamically regulates immune function. The gut’s immune system also provides an effective defense against harmful pathogens entering the GI tract while maintaining immune homeostasis to avoid exaggerated immune reaction to innocuous food and commensal antigens which are important causes of inflammatory disorders such as coeliac disease and inflammatory bowel diseases (IBD). Various ion channels have been detected in multiple cell types throughout the GI tract. By regulating membrane properties and intracellular biochemical signaling, ion channels play a critical role in synchronized signaling among diverse cellular components in the gut that orchestrates the GI immune response. This work focuses on the role of ion channels in immune cells, non-immune resident cells, and neuroimmune interactions in the gut at the steady state and pathological conditions. Understanding the cellular and molecular basis of ion channel signaling in these immune-related pathways and initial testing of pharmacological intervention will facilitate the development of ion channel–based therapeutic approaches for the treatment of intestinal inflammation.
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spelling pubmed-97235122022-12-07 Ion channel regulation of gut immunity Feng, Jing Xie, Zili Hu, Hongzhen J Gen Physiol Review Mounting evidence indicates that gastrointestinal (GI) homeostasis hinges on communications among many cellular networks including the intestinal epithelium, the immune system, and both intrinsic and extrinsic nerves innervating the gut. The GI tract, especially the colon, is the home base for gut microbiome which dynamically regulates immune function. The gut’s immune system also provides an effective defense against harmful pathogens entering the GI tract while maintaining immune homeostasis to avoid exaggerated immune reaction to innocuous food and commensal antigens which are important causes of inflammatory disorders such as coeliac disease and inflammatory bowel diseases (IBD). Various ion channels have been detected in multiple cell types throughout the GI tract. By regulating membrane properties and intracellular biochemical signaling, ion channels play a critical role in synchronized signaling among diverse cellular components in the gut that orchestrates the GI immune response. This work focuses on the role of ion channels in immune cells, non-immune resident cells, and neuroimmune interactions in the gut at the steady state and pathological conditions. Understanding the cellular and molecular basis of ion channel signaling in these immune-related pathways and initial testing of pharmacological intervention will facilitate the development of ion channel–based therapeutic approaches for the treatment of intestinal inflammation. Rockefeller University Press 2022-12-02 /pmc/articles/PMC9723512/ /pubmed/36459135 http://dx.doi.org/10.1085/jgp.202113042 Text en © 2022 Feng et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Feng, Jing
Xie, Zili
Hu, Hongzhen
Ion channel regulation of gut immunity
title Ion channel regulation of gut immunity
title_full Ion channel regulation of gut immunity
title_fullStr Ion channel regulation of gut immunity
title_full_unstemmed Ion channel regulation of gut immunity
title_short Ion channel regulation of gut immunity
title_sort ion channel regulation of gut immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723512/
https://www.ncbi.nlm.nih.gov/pubmed/36459135
http://dx.doi.org/10.1085/jgp.202113042
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