A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5′ splice site identity

The spliceosome undergoes extensive rearrangements as it assembles onto precursor messenger RNAs. In the earliest assembly step, U1snRNA identifies the 5′ splice site. However, U1snRNA leaves the spliceosome relatively early in assembly, and 5′ splice site identity is subsequently maintained through...

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Detalles Bibliográficos
Autores principales: Cartwright-Acar, Catiana H, Osterhoudt, Kenneth, Suzuki, Jessie M N G L, Gomez, Destiny R, Katzman, Sol, Zahler, Alan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723624/
https://www.ncbi.nlm.nih.gov/pubmed/36321655
http://dx.doi.org/10.1093/nar/gkac991

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