A PAM-free CRISPR/Cas12a ultra-specific activation mode based on toehold-mediated strand displacement and branch migration

CRISPR (clustered regularly interspaced short palindromic repeats) technology has achieved great breakthroughs in terms of convenience and sensitivity; it is becoming the most promising molecular tool. However, only two CRISPR activation modes (single and double stranded) are available, and they hav...

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Detalles Bibliográficos
Autores principales: Wu, You, Luo, Wang, Weng, Zhi, Guo, Yongcan, Yu, Hongyan, Zhao, Rong, Zhang, Li, Zhao, Jie, Bai, Dan, Zhou, Xi, Song, Lin, Chen, Kena, Li, Junjie, Yang, Yujun, Xie, Guoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723625/
https://www.ncbi.nlm.nih.gov/pubmed/36318259
http://dx.doi.org/10.1093/nar/gkac886

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