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High-affinity binding at quadruplex–duplex junctions: rather the rule than the exception

Quadruplex-duplex (Q–D) junctions constitute unique structural motifs in genomic sequences. Through comprehensive calorimetric as well as high-resolution NMR structural studies, Q–D junctions with a hairpin-type snapback loop coaxially stacked onto an outer G-tetrad were identified to be most effect...

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Detalles Bibliográficos
Autores principales: Vianney, Yoanes Maria, Weisz, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723630/
https://www.ncbi.nlm.nih.gov/pubmed/36416262
http://dx.doi.org/10.1093/nar/gkac1088