SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis

Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential for male germ cell differentiation in mice. Germ-cell conditional knockout (cKO) of Smg6 induces extensive transcriptome misregulatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Lehtiniemi, Tiina, Bourgery, Matthieu, Ma, Lin, Ahmedani, Ammar, Mäkelä, Margareeta, Asteljoki, Juho, Olotu, Opeyemi, Laasanen, Samuli, Zhang, Fu-Ping, Tan, Kun, Chousal, Jennifer N, Burow, Dana, Koskinen, Satu, Laiho, Asta, Elo, Laura L, Chalmel, Frédéric, Wilkinson, Miles F, Kotaja, Noora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723633/
https://www.ncbi.nlm.nih.gov/pubmed/36259644
http://dx.doi.org/10.1093/nar/gkac900

Ejemplares similares

Ejemplares similares