Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia were not only refractory to macrophage-mediated engulfment and removal, but they also paralyzed the ability of macropha...

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Detalles Bibliográficos
Autores principales: Schloesser, Daniela, Lindenthal, Laura, Sauer, Julia, Chung, Kyoung-Jin, Chavakis, Triantafyllos, Griesser, Eva, Baskaran, Praveen, Maier-Habelsberger, Ulrike, Fundel-Clemens, Katrin, Schlotthauer, Ines, Watson, Carolin Kirsten, Swee, Lee Kim, Igney, Frederik, Park, John Edward, Huber-Lang, Markus S., Thomas, Matthew-James, El Kasmi, Karim Christian, Murray, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723804/
https://www.ncbi.nlm.nih.gov/pubmed/36459066
http://dx.doi.org/10.1083/jcb.202207097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723804/
https://www.ncbi.nlm.nih.gov/pubmed/36459066
http://dx.doi.org/10.1083/jcb.202207097

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