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Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis
Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia were not only refractory to macrophage-mediated engulfment and removal, but they also paralyzed the ability of macropha...
Autores principales: | Schloesser, Daniela, Lindenthal, Laura, Sauer, Julia, Chung, Kyoung-Jin, Chavakis, Triantafyllos, Griesser, Eva, Baskaran, Praveen, Maier-Habelsberger, Ulrike, Fundel-Clemens, Katrin, Schlotthauer, Ines, Watson, Carolin Kirsten, Swee, Lee Kim, Igney, Frederik, Park, John Edward, Huber-Lang, Markus S., Thomas, Matthew-James, El Kasmi, Karim Christian, Murray, Peter J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723804/ https://www.ncbi.nlm.nih.gov/pubmed/36459066 http://dx.doi.org/10.1083/jcb.202207097 |
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