Antidiabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1

Metformin, an antidiabetic drug, shows some potent antitumor effects. However, the molecular mechanism of metformin in tumor suppression has not been clarified. Here, we provided evidence using in vitro and in vivo data that metformin inhibited mevalonate pathway by downregulation of 3-hydroxy-3-met...

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Detalles Bibliográficos
Autores principales: Chen, Yiyan, Li, Min, Yang, Yanying, Lu, Yan, Li, Xiaoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723917/
https://www.ncbi.nlm.nih.gov/pubmed/36356901
http://dx.doi.org/10.1016/j.jbc.2022.102678

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