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Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men

The contribution of pyridoxine on various human disorders has been revealed in so many studies; however, this contribution on poor semen quality has yet to be investigated. Here, we intended to measure the level of seminal plasma pyridoxine (SPP) in men with oligozoospermia compared to normozoosperm...

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Detalles Bibliográficos
Autores principales: Banihani, Saleem A., Aljabali, Shefa’ M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723925/
https://www.ncbi.nlm.nih.gov/pubmed/36483303
http://dx.doi.org/10.1016/j.heliyon.2022.e11983
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author Banihani, Saleem A.
Aljabali, Shefa’ M.
author_facet Banihani, Saleem A.
Aljabali, Shefa’ M.
author_sort Banihani, Saleem A.
collection PubMed
description The contribution of pyridoxine on various human disorders has been revealed in so many studies; however, this contribution on poor semen quality has yet to be investigated. Here, we intended to measure the level of seminal plasma pyridoxine (SPP) in men with oligozoospermia compared to normozoospermic men. Thirty-three men with oligozoospermia and forty-three normozoospermic men were randomly enrolled in this study. Collected semen were tested for sperm motility, sperm concentration, semen volume, and pyridoxine status. Liquid chromatography with tandem mass spectrometry was used to measure SPP in the collected samples. There was a significant reduction (p < 0.0001) in the concentrations of SPP in men with oligozoospermia (0.79 ± 0.41 μg L(−1)) compared to normozoospermic men (3.17 ± 0.96 μg L(−1)). Besides, SPP was not significantly correlated (p > 0.05) with sperm motility, sperm concentration, and semen volume in both tested groups, but, independently, it was found to be positively correlated (p = 0.0154) with male age in oligozoospermic group. Men with oligozoospermia had lower level of SPP compared to normozoospermic men. These results may open a new research gate for the use of pyridoxine in the management of male infertility.
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spelling pubmed-97239252022-12-07 Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men Banihani, Saleem A. Aljabali, Shefa’ M. Heliyon Research Article The contribution of pyridoxine on various human disorders has been revealed in so many studies; however, this contribution on poor semen quality has yet to be investigated. Here, we intended to measure the level of seminal plasma pyridoxine (SPP) in men with oligozoospermia compared to normozoospermic men. Thirty-three men with oligozoospermia and forty-three normozoospermic men were randomly enrolled in this study. Collected semen were tested for sperm motility, sperm concentration, semen volume, and pyridoxine status. Liquid chromatography with tandem mass spectrometry was used to measure SPP in the collected samples. There was a significant reduction (p < 0.0001) in the concentrations of SPP in men with oligozoospermia (0.79 ± 0.41 μg L(−1)) compared to normozoospermic men (3.17 ± 0.96 μg L(−1)). Besides, SPP was not significantly correlated (p > 0.05) with sperm motility, sperm concentration, and semen volume in both tested groups, but, independently, it was found to be positively correlated (p = 0.0154) with male age in oligozoospermic group. Men with oligozoospermia had lower level of SPP compared to normozoospermic men. These results may open a new research gate for the use of pyridoxine in the management of male infertility. Elsevier 2022-12-01 /pmc/articles/PMC9723925/ /pubmed/36483303 http://dx.doi.org/10.1016/j.heliyon.2022.e11983 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Banihani, Saleem A.
Aljabali, Shefa’ M.
Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men
title Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men
title_full Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men
title_fullStr Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men
title_full_unstemmed Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men
title_short Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men
title_sort men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723925/
https://www.ncbi.nlm.nih.gov/pubmed/36483303
http://dx.doi.org/10.1016/j.heliyon.2022.e11983
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