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Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis

OBJECTIVES: To define variables associated with perceived risk of developing rheumatoid arthritis (RA) in first-degree relatives (FDRs) of patients with RA. METHODS: Patients with RA and their FDRs were invited to complete cross-sectional surveys. FDR and index patient responses were linked. FDRs’ p...

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Autores principales: Bunnewell, Sarah, Wells, Imogen, Zemedikun, Dawit, Simons, Gwenda, Mallen, Christian D, Raza, Karim, Falahee, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723950/
https://www.ncbi.nlm.nih.gov/pubmed/36597990
http://dx.doi.org/10.1136/rmdopen-2022-002606
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author Bunnewell, Sarah
Wells, Imogen
Zemedikun, Dawit
Simons, Gwenda
Mallen, Christian D
Raza, Karim
Falahee, Marie
author_facet Bunnewell, Sarah
Wells, Imogen
Zemedikun, Dawit
Simons, Gwenda
Mallen, Christian D
Raza, Karim
Falahee, Marie
author_sort Bunnewell, Sarah
collection PubMed
description OBJECTIVES: To define variables associated with perceived risk of developing rheumatoid arthritis (RA) in first-degree relatives (FDRs) of patients with RA. METHODS: Patients with RA and their FDRs were invited to complete cross-sectional surveys. FDR and index patient responses were linked. FDRs’ perceived absolute risk, comparative risk, experiential risk and worry about risk were assessed using 5-point Likert scales. FDR predictor variables included demographics, illness perceptions and psychosocial variables. Patient predictors of FDR perceived risk were assessed. Binary logistic regression examined the relationship between FDR characteristics and perceived risk of RA. Generalised estimating equations assessed whether patient variables predicted FDR’s perceived risk. RESULTS: 396 FDRs returned a survey. 395 FDRs provided sufficient data and were included in analysis. Paired data from 213 patients were available for 291 of these FDRs. All measures of perceived risk were inter-correlated. 65.2% of FDRs perceived themselves to be ‘likely’ or ‘very likely’ to develop RA in their lifetime. Relationship with index patient, high health anxiety, female gender, long perceived RA duration, high perceived concern about RA, negative perceived emotional impact of RA and low perceptions of how well treatment would control RA were all associated with increased FDRs’ perceived risk. Patient characteristics did not associate with FDRs’ risk perceptions. CONCLUSIONS: FDRs’ perceived risk of RA was high. Key predictors included being a child of a patient with RA, higher health anxiety and lower perceptions of RA treatment control. An understanding of these predictors will inform the development of tailored risk communication resources and preventive clinical strategies for RA.
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spelling pubmed-97239502022-12-07 Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis Bunnewell, Sarah Wells, Imogen Zemedikun, Dawit Simons, Gwenda Mallen, Christian D Raza, Karim Falahee, Marie RMD Open Rheumatoid Arthritis OBJECTIVES: To define variables associated with perceived risk of developing rheumatoid arthritis (RA) in first-degree relatives (FDRs) of patients with RA. METHODS: Patients with RA and their FDRs were invited to complete cross-sectional surveys. FDR and index patient responses were linked. FDRs’ perceived absolute risk, comparative risk, experiential risk and worry about risk were assessed using 5-point Likert scales. FDR predictor variables included demographics, illness perceptions and psychosocial variables. Patient predictors of FDR perceived risk were assessed. Binary logistic regression examined the relationship between FDR characteristics and perceived risk of RA. Generalised estimating equations assessed whether patient variables predicted FDR’s perceived risk. RESULTS: 396 FDRs returned a survey. 395 FDRs provided sufficient data and were included in analysis. Paired data from 213 patients were available for 291 of these FDRs. All measures of perceived risk were inter-correlated. 65.2% of FDRs perceived themselves to be ‘likely’ or ‘very likely’ to develop RA in their lifetime. Relationship with index patient, high health anxiety, female gender, long perceived RA duration, high perceived concern about RA, negative perceived emotional impact of RA and low perceptions of how well treatment would control RA were all associated with increased FDRs’ perceived risk. Patient characteristics did not associate with FDRs’ risk perceptions. CONCLUSIONS: FDRs’ perceived risk of RA was high. Key predictors included being a child of a patient with RA, higher health anxiety and lower perceptions of RA treatment control. An understanding of these predictors will inform the development of tailored risk communication resources and preventive clinical strategies for RA. BMJ Publishing Group 2022-12-05 /pmc/articles/PMC9723950/ /pubmed/36597990 http://dx.doi.org/10.1136/rmdopen-2022-002606 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Rheumatoid Arthritis
Bunnewell, Sarah
Wells, Imogen
Zemedikun, Dawit
Simons, Gwenda
Mallen, Christian D
Raza, Karim
Falahee, Marie
Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis
title Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis
title_full Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis
title_fullStr Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis
title_full_unstemmed Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis
title_short Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis
title_sort predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis
topic Rheumatoid Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723950/
https://www.ncbi.nlm.nih.gov/pubmed/36597990
http://dx.doi.org/10.1136/rmdopen-2022-002606
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