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Epidural intracranial abscesses and multiple bone metastases caused by disseminated Mycobacterium avium complex infection: illustrative case
BACKGROUND: Mycobacterium avium complex (MAC) generally causes localized pulmonary infections in immunocompromised hosts, but rarely in other organs and tissues, which is called disseminated MAC infection. OBSERVATIONS: The authors herein present a 48-year-old male patient with disseminated MAC infe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association of Neurological Surgeons
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724007/ https://www.ncbi.nlm.nih.gov/pubmed/36471577 http://dx.doi.org/10.3171/CASE22407 |
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author | Nomura, Yu Mizukami, Ai Ueno, Kota Watanabe, Ryota Kinoshita, Shohei Fujiwara, Nozomi Kakuta, Kiyohide Morita, Takahiro Asano, Kenichiro Saito, Atsushi |
author_facet | Nomura, Yu Mizukami, Ai Ueno, Kota Watanabe, Ryota Kinoshita, Shohei Fujiwara, Nozomi Kakuta, Kiyohide Morita, Takahiro Asano, Kenichiro Saito, Atsushi |
author_sort | Nomura, Yu |
collection | PubMed |
description | BACKGROUND: Mycobacterium avium complex (MAC) generally causes localized pulmonary infections in immunocompromised hosts, but rarely in other organs and tissues, which is called disseminated MAC infection. OBSERVATIONS: The authors herein present a 48-year-old male patient with disseminated MAC infectious lesions in the lungs and on the cranial, vertebral, femoral, and pelvic bones, a normal CD4 count, and immunopositivity for the interferon-ɤ (IFN-ɤ) neutralization antibody. Cranial lesions were multiple osteolytic lesions associated with abscesses in the cranial bones. The patient initially received conservative treatment with multiple antibiotics; however, cranial lesions worsened. Therefore, multiple cranial lesions were removed via osteoplastic craniectomy and the postoperative course was uneventful. Pathological findings revealed MAC infection. The patient was discharged without recurrence or complications. LESSONS: Multiple cranial MAC dissemination with immunopositivity for the IFN-ɤ antibody is rare. The authors herein present the clinical course of a rare surgical case of MAC dissemination with a literature review. |
format | Online Article Text |
id | pubmed-9724007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association of Neurological Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-97240072022-12-07 Epidural intracranial abscesses and multiple bone metastases caused by disseminated Mycobacterium avium complex infection: illustrative case Nomura, Yu Mizukami, Ai Ueno, Kota Watanabe, Ryota Kinoshita, Shohei Fujiwara, Nozomi Kakuta, Kiyohide Morita, Takahiro Asano, Kenichiro Saito, Atsushi J Neurosurg Case Lessons Case Lesson BACKGROUND: Mycobacterium avium complex (MAC) generally causes localized pulmonary infections in immunocompromised hosts, but rarely in other organs and tissues, which is called disseminated MAC infection. OBSERVATIONS: The authors herein present a 48-year-old male patient with disseminated MAC infectious lesions in the lungs and on the cranial, vertebral, femoral, and pelvic bones, a normal CD4 count, and immunopositivity for the interferon-ɤ (IFN-ɤ) neutralization antibody. Cranial lesions were multiple osteolytic lesions associated with abscesses in the cranial bones. The patient initially received conservative treatment with multiple antibiotics; however, cranial lesions worsened. Therefore, multiple cranial lesions were removed via osteoplastic craniectomy and the postoperative course was uneventful. Pathological findings revealed MAC infection. The patient was discharged without recurrence or complications. LESSONS: Multiple cranial MAC dissemination with immunopositivity for the IFN-ɤ antibody is rare. The authors herein present the clinical course of a rare surgical case of MAC dissemination with a literature review. American Association of Neurological Surgeons 2022-12-05 /pmc/articles/PMC9724007/ /pubmed/36471577 http://dx.doi.org/10.3171/CASE22407 Text en © 2022 The authors https://creativecommons.org/licenses/by-nc-nd/4.0/CC BY-NC-ND 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Case Lesson Nomura, Yu Mizukami, Ai Ueno, Kota Watanabe, Ryota Kinoshita, Shohei Fujiwara, Nozomi Kakuta, Kiyohide Morita, Takahiro Asano, Kenichiro Saito, Atsushi Epidural intracranial abscesses and multiple bone metastases caused by disseminated Mycobacterium avium complex infection: illustrative case |
title | Epidural intracranial abscesses and multiple bone metastases caused by disseminated Mycobacterium avium complex infection: illustrative case |
title_full | Epidural intracranial abscesses and multiple bone metastases caused by disseminated Mycobacterium avium complex infection: illustrative case |
title_fullStr | Epidural intracranial abscesses and multiple bone metastases caused by disseminated Mycobacterium avium complex infection: illustrative case |
title_full_unstemmed | Epidural intracranial abscesses and multiple bone metastases caused by disseminated Mycobacterium avium complex infection: illustrative case |
title_short | Epidural intracranial abscesses and multiple bone metastases caused by disseminated Mycobacterium avium complex infection: illustrative case |
title_sort | epidural intracranial abscesses and multiple bone metastases caused by disseminated mycobacterium avium complex infection: illustrative case |
topic | Case Lesson |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724007/ https://www.ncbi.nlm.nih.gov/pubmed/36471577 http://dx.doi.org/10.3171/CASE22407 |
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