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Total Synthesis of Penicyclone A Using a Double Grignard Reaction
[Image: see text] We describe the first total synthesis of penicyclone A, a novel deep-sea fungus-derived polyketide, and a reevaluation of its antimicrobial activity. The synthesis of this unique spirolactone was achieved in 10 steps starting from a known d-ribose derivative. The key steps include...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724088/ https://www.ncbi.nlm.nih.gov/pubmed/36383733 http://dx.doi.org/10.1021/acs.joc.2c02200 |