Monkeypox: An emerging zoonotic pathogen

Monkeypox virus (MPXV), which belongs to the orthopoxvirus genus, causes zoonotic viral disease. This review discusses the biology, epidemiology, and evolution of MPXV infection, particularly cellular, human, and viral factors, virus transmission dynamics, infection, and persistence in nature. This...

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Autores principales: Beig, Masoumeh, Mohammadi, Mehrdad, Nafe Monfared, Fatemeh, Nasereslami, Somaieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724206/
https://www.ncbi.nlm.nih.gov/pubmed/36483104
http://dx.doi.org/10.5501/wjv.v11.i6.426
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author Beig, Masoumeh
Mohammadi, Mehrdad
Nafe Monfared, Fatemeh
Nasereslami, Somaieh
author_facet Beig, Masoumeh
Mohammadi, Mehrdad
Nafe Monfared, Fatemeh
Nasereslami, Somaieh
author_sort Beig, Masoumeh
collection PubMed
description Monkeypox virus (MPXV), which belongs to the orthopoxvirus genus, causes zoonotic viral disease. This review discusses the biology, epidemiology, and evolution of MPXV infection, particularly cellular, human, and viral factors, virus transmission dynamics, infection, and persistence in nature. This review also describes the role of recombination, gene loss, and gene gain in MPXV evol-vement and the role of signal transduction in MPXV infection and provides an overview of the current access to therapeutic options for the treatment and prevention of MPXV. Finally, this review highlighted gaps in knowledge and proposed future research endeavors to address the unresolved questions.
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spelling pubmed-97242062022-12-07 Monkeypox: An emerging zoonotic pathogen Beig, Masoumeh Mohammadi, Mehrdad Nafe Monfared, Fatemeh Nasereslami, Somaieh World J Virol Minireviews Monkeypox virus (MPXV), which belongs to the orthopoxvirus genus, causes zoonotic viral disease. This review discusses the biology, epidemiology, and evolution of MPXV infection, particularly cellular, human, and viral factors, virus transmission dynamics, infection, and persistence in nature. This review also describes the role of recombination, gene loss, and gene gain in MPXV evol-vement and the role of signal transduction in MPXV infection and provides an overview of the current access to therapeutic options for the treatment and prevention of MPXV. Finally, this review highlighted gaps in knowledge and proposed future research endeavors to address the unresolved questions. Baishideng Publishing Group Inc 2022-11-25 2022-11-25 /pmc/articles/PMC9724206/ /pubmed/36483104 http://dx.doi.org/10.5501/wjv.v11.i6.426 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Beig, Masoumeh
Mohammadi, Mehrdad
Nafe Monfared, Fatemeh
Nasereslami, Somaieh
Monkeypox: An emerging zoonotic pathogen
title Monkeypox: An emerging zoonotic pathogen
title_full Monkeypox: An emerging zoonotic pathogen
title_fullStr Monkeypox: An emerging zoonotic pathogen
title_full_unstemmed Monkeypox: An emerging zoonotic pathogen
title_short Monkeypox: An emerging zoonotic pathogen
title_sort monkeypox: an emerging zoonotic pathogen
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724206/
https://www.ncbi.nlm.nih.gov/pubmed/36483104
http://dx.doi.org/10.5501/wjv.v11.i6.426
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