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Prognostic value of pretreatment systemic inflammatory markers in patients with stage I endometrial cancer
Objective: Evaluate the prognostic value of monocyte-lymphocyte ratio (MLR) in patients with stage I endometrial cancer. Method: Data from 225 patients with stage I endometrioid endometrial cancer who underwent surgical resection between January 2010 and December 2020 were reviewed. The receiver ope...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724239/ https://www.ncbi.nlm.nih.gov/pubmed/36483600 http://dx.doi.org/10.7150/ijms.78182 |
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author | Ahn, Jung Hwan Lee, Sung Jong Yoon, Joo Hee Park, Dong Choon Kim, Sang Il |
author_facet | Ahn, Jung Hwan Lee, Sung Jong Yoon, Joo Hee Park, Dong Choon Kim, Sang Il |
author_sort | Ahn, Jung Hwan |
collection | PubMed |
description | Objective: Evaluate the prognostic value of monocyte-lymphocyte ratio (MLR) in patients with stage I endometrial cancer. Method: Data from 225 patients with stage I endometrioid endometrial cancer who underwent surgical resection between January 2010 and December 2020 were reviewed. The receiver operating characteristic (ROC) curves were generated for the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and MLR. Optimal cut-off values were determined as the points at which the Youden index (sensitivity + specificity - 1) was maximal. Based on the results of the ROC curve analysis, the patients were grouped into high MLR and low MLR groups. Recurrence rate, and disease-free survival were compared between the two groups. The prognostic factors were investigated using univariate and multivariate Cox proportional hazards model. Results: The optimal cut-off value of MLR was 0.220 (AUC, 0.835; p < 0.001). Significantly more patients in the high MLR group experienced recurrence (20.3% vs. 1.9%, p < 0.0001). In multivariate analysis, grade, depth of myometrial invasion, adjuvant RT, and high MLR were independent prognostic factors for disease-free survival. Conclusion: Elevated MLR was significantly associated poor clinical outcomes in patients with stage I endometrioid endometrial cancer. Our findings suggest that MLR may be clinically reliable and useful as an independent prognostic marker for patients with stage I endometrioid endometrial cancer. |
format | Online Article Text |
id | pubmed-9724239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-97242392022-12-07 Prognostic value of pretreatment systemic inflammatory markers in patients with stage I endometrial cancer Ahn, Jung Hwan Lee, Sung Jong Yoon, Joo Hee Park, Dong Choon Kim, Sang Il Int J Med Sci Research Paper Objective: Evaluate the prognostic value of monocyte-lymphocyte ratio (MLR) in patients with stage I endometrial cancer. Method: Data from 225 patients with stage I endometrioid endometrial cancer who underwent surgical resection between January 2010 and December 2020 were reviewed. The receiver operating characteristic (ROC) curves were generated for the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and MLR. Optimal cut-off values were determined as the points at which the Youden index (sensitivity + specificity - 1) was maximal. Based on the results of the ROC curve analysis, the patients were grouped into high MLR and low MLR groups. Recurrence rate, and disease-free survival were compared between the two groups. The prognostic factors were investigated using univariate and multivariate Cox proportional hazards model. Results: The optimal cut-off value of MLR was 0.220 (AUC, 0.835; p < 0.001). Significantly more patients in the high MLR group experienced recurrence (20.3% vs. 1.9%, p < 0.0001). In multivariate analysis, grade, depth of myometrial invasion, adjuvant RT, and high MLR were independent prognostic factors for disease-free survival. Conclusion: Elevated MLR was significantly associated poor clinical outcomes in patients with stage I endometrioid endometrial cancer. Our findings suggest that MLR may be clinically reliable and useful as an independent prognostic marker for patients with stage I endometrioid endometrial cancer. Ivyspring International Publisher 2022-11-07 /pmc/articles/PMC9724239/ /pubmed/36483600 http://dx.doi.org/10.7150/ijms.78182 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Ahn, Jung Hwan Lee, Sung Jong Yoon, Joo Hee Park, Dong Choon Kim, Sang Il Prognostic value of pretreatment systemic inflammatory markers in patients with stage I endometrial cancer |
title | Prognostic value of pretreatment systemic inflammatory markers in patients with stage I endometrial cancer |
title_full | Prognostic value of pretreatment systemic inflammatory markers in patients with stage I endometrial cancer |
title_fullStr | Prognostic value of pretreatment systemic inflammatory markers in patients with stage I endometrial cancer |
title_full_unstemmed | Prognostic value of pretreatment systemic inflammatory markers in patients with stage I endometrial cancer |
title_short | Prognostic value of pretreatment systemic inflammatory markers in patients with stage I endometrial cancer |
title_sort | prognostic value of pretreatment systemic inflammatory markers in patients with stage i endometrial cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724239/ https://www.ncbi.nlm.nih.gov/pubmed/36483600 http://dx.doi.org/10.7150/ijms.78182 |
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