The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production

Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that HDPs can also indirectly protect hosts by modulating their immune responses. Due to these dual roles, HDPs have been consid...

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Detalles Bibliográficos
Autores principales: Wu, Di, Fu, Linglong, Wen, Weizhang, Dong, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724304/
https://www.ncbi.nlm.nih.gov/pubmed/36474280
http://dx.doi.org/10.1186/s40104-022-00796-y
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author Wu, Di
Fu, Linglong
Wen, Weizhang
Dong, Na
author_facet Wu, Di
Fu, Linglong
Wen, Weizhang
Dong, Na
author_sort Wu, Di
collection PubMed
description Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that HDPs can also indirectly protect hosts by modulating their immune responses. Due to these dual roles, HDPs have been considered one of the most promising antibiotic substitutes to improve growth performance, intestinal health, and immunity in farm animals. This review describes the antimicrobial and immunomodulatory roles of host defense peptides and their recent applications in animal production.
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spelling pubmed-97243042022-12-07 The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production Wu, Di Fu, Linglong Wen, Weizhang Dong, Na J Anim Sci Biotechnol Review Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that HDPs can also indirectly protect hosts by modulating their immune responses. Due to these dual roles, HDPs have been considered one of the most promising antibiotic substitutes to improve growth performance, intestinal health, and immunity in farm animals. This review describes the antimicrobial and immunomodulatory roles of host defense peptides and their recent applications in animal production. BioMed Central 2022-12-06 /pmc/articles/PMC9724304/ /pubmed/36474280 http://dx.doi.org/10.1186/s40104-022-00796-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wu, Di
Fu, Linglong
Wen, Weizhang
Dong, Na
The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production
title The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production
title_full The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production
title_fullStr The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production
title_full_unstemmed The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production
title_short The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production
title_sort dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724304/
https://www.ncbi.nlm.nih.gov/pubmed/36474280
http://dx.doi.org/10.1186/s40104-022-00796-y
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