Comprehensive computational analysis of epigenetic descriptors affecting CRISPR-Cas9 off-target activity

BACKGROUND: A common issue in CRISPR-Cas9 genome editing is off-target activity, which prevents the widespread use of CRISPR-Cas9 in medical applications. Among other factors, primary chromatin structure and epigenetics may influence off-target activity. METHODS: In this work, we utilize crisprSQL,...

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Detalles Bibliográficos
Autores principales: Mak, Jeffrey K., Störtz, Florian, Minary, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724382/
https://www.ncbi.nlm.nih.gov/pubmed/36474180
http://dx.doi.org/10.1186/s12864-022-09012-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724382/
https://www.ncbi.nlm.nih.gov/pubmed/36474180
http://dx.doi.org/10.1186/s12864-022-09012-7

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