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Comprehensive computational analysis of epigenetic descriptors affecting CRISPR-Cas9 off-target activity

BACKGROUND: A common issue in CRISPR-Cas9 genome editing is off-target activity, which prevents the widespread use of CRISPR-Cas9 in medical applications. Among other factors, primary chromatin structure and epigenetics may influence off-target activity. METHODS: In this work, we utilize crisprSQL,...

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Detalles Bibliográficos
Autores principales:	Mak, Jeffrey K., Störtz, Florian, Minary, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724382/ https://www.ncbi.nlm.nih.gov/pubmed/36474180 http://dx.doi.org/10.1186/s12864-022-09012-7

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