Conversion therapy for advanced penile cancer with tislelizumab combined with chemotherapy: A case report and review of literature

BACKGROUND: Locally advanced penile squamous cell carcinoma with unresectable inguinal lymph node metastasis has a poor prognosis, and surgical treatment alone offers limited benefits. Effective conversion therapy regimens are urgently needed. CASE SUMMARY: We describe a locally advanced penile squa...

Descripción completa

Detalles Bibliográficos
Autores principales: Long, Xiang-Yu, Zhang, Shuang, Tang, Lian-Sha, Li, Xiang, Liu, Ji-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724507/
https://www.ncbi.nlm.nih.gov/pubmed/36483823
http://dx.doi.org/10.12998/wjcc.v10.i33.12305
_version_ 1784844432296640512
author Long, Xiang-Yu
Zhang, Shuang
Tang, Lian-Sha
Li, Xiang
Liu, Ji-Yan
author_facet Long, Xiang-Yu
Zhang, Shuang
Tang, Lian-Sha
Li, Xiang
Liu, Ji-Yan
author_sort Long, Xiang-Yu
collection PubMed
description BACKGROUND: Locally advanced penile squamous cell carcinoma with unresectable inguinal lymph node metastasis has a poor prognosis, and surgical treatment alone offers limited benefits. Effective conversion therapy regimens are urgently needed. CASE SUMMARY: We describe a locally advanced penile squamous cell carcinoma patient with bulky, fixed inguinal lymph node metastasis complicated with genital skin ulcers who underwent inguinal lymph node dissection and achieved a pathological complete response with conversion therapy comprising immunotherapy plus chemotherapy. CONCLUSION: For unresectable locally advanced penile squamous cell carcinoma, neoadjuvant immunotherapy combined with chemotherapy is a potential treatment approach. Biomarkers of immunotherapy efficacy need to be explored, and clinical trials are needed to test these strategies.
format Online
Article
Text
id pubmed-9724507
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-97245072022-12-07 Conversion therapy for advanced penile cancer with tislelizumab combined with chemotherapy: A case report and review of literature Long, Xiang-Yu Zhang, Shuang Tang, Lian-Sha Li, Xiang Liu, Ji-Yan World J Clin Cases Case Report BACKGROUND: Locally advanced penile squamous cell carcinoma with unresectable inguinal lymph node metastasis has a poor prognosis, and surgical treatment alone offers limited benefits. Effective conversion therapy regimens are urgently needed. CASE SUMMARY: We describe a locally advanced penile squamous cell carcinoma patient with bulky, fixed inguinal lymph node metastasis complicated with genital skin ulcers who underwent inguinal lymph node dissection and achieved a pathological complete response with conversion therapy comprising immunotherapy plus chemotherapy. CONCLUSION: For unresectable locally advanced penile squamous cell carcinoma, neoadjuvant immunotherapy combined with chemotherapy is a potential treatment approach. Biomarkers of immunotherapy efficacy need to be explored, and clinical trials are needed to test these strategies. Baishideng Publishing Group Inc 2022-11-26 2022-11-26 /pmc/articles/PMC9724507/ /pubmed/36483823 http://dx.doi.org/10.12998/wjcc.v10.i33.12305 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Long, Xiang-Yu
Zhang, Shuang
Tang, Lian-Sha
Li, Xiang
Liu, Ji-Yan
Conversion therapy for advanced penile cancer with tislelizumab combined with chemotherapy: A case report and review of literature
title Conversion therapy for advanced penile cancer with tislelizumab combined with chemotherapy: A case report and review of literature
title_full Conversion therapy for advanced penile cancer with tislelizumab combined with chemotherapy: A case report and review of literature
title_fullStr Conversion therapy for advanced penile cancer with tislelizumab combined with chemotherapy: A case report and review of literature
title_full_unstemmed Conversion therapy for advanced penile cancer with tislelizumab combined with chemotherapy: A case report and review of literature
title_short Conversion therapy for advanced penile cancer with tislelizumab combined with chemotherapy: A case report and review of literature
title_sort conversion therapy for advanced penile cancer with tislelizumab combined with chemotherapy: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724507/
https://www.ncbi.nlm.nih.gov/pubmed/36483823
http://dx.doi.org/10.12998/wjcc.v10.i33.12305
work_keys_str_mv AT longxiangyu conversiontherapyforadvancedpenilecancerwithtislelizumabcombinedwithchemotherapyacasereportandreviewofliterature
AT zhangshuang conversiontherapyforadvancedpenilecancerwithtislelizumabcombinedwithchemotherapyacasereportandreviewofliterature
AT tangliansha conversiontherapyforadvancedpenilecancerwithtislelizumabcombinedwithchemotherapyacasereportandreviewofliterature
AT lixiang conversiontherapyforadvancedpenilecancerwithtislelizumabcombinedwithchemotherapyacasereportandreviewofliterature
AT liujiyan conversiontherapyforadvancedpenilecancerwithtislelizumabcombinedwithchemotherapyacasereportandreviewofliterature

Ejemplares similares