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Characteristics of the population with mild COVID-19 symptoms eligible for early treatment attended in a single center in Northern Italy

After more than two years from the first COVID-19 detected case in Brescia, Northern Italy, monoclonal antibodies and antiviral therapy aimed at early treatment of mild COVID-19 in patients at risk of progression and of hospitalization has been approved in Italy. Here we report the characteristics o...

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Autores principales: Magro, Paola, Degli Antoni, M., Formenti, B., Viola, F., Castelli, F., Amadasi, S., Quiros-Roldan, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724552/
https://www.ncbi.nlm.nih.gov/pubmed/36521328
http://dx.doi.org/10.1016/j.jiph.2022.11.027
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author Magro, Paola
Degli Antoni, M.
Formenti, B.
Viola, F.
Castelli, F.
Amadasi, S.
Quiros-Roldan, E.
author_facet Magro, Paola
Degli Antoni, M.
Formenti, B.
Viola, F.
Castelli, F.
Amadasi, S.
Quiros-Roldan, E.
author_sort Magro, Paola
collection PubMed
description After more than two years from the first COVID-19 detected case in Brescia, Northern Italy, monoclonal antibodies and antiviral therapy aimed at early treatment of mild COVID-19 in patients at risk of progression and of hospitalization has been approved in Italy. Here we report the characteristics of the population eligible for the COVID-19 early treatments at our COVID-19 Early Therapy Unit of the Infectious Diseases Department of the ASST Spedali Civili of Brescia, with the aim to evaluate the characteristics of the foreign and native groups. Up to March the 31st, 2022, a total of 559 patients were referred to our Unit for COVID-19 early treatment, where 7.6% were foreigners, a group significantly younger than natives (p < 0.05). Particular differences are noticed between the native and the foreign population, where people aged > 65 years old were significantly more frequent among italians (39.7% vs 16.3%, p < 0.01), while primary or acquired immunodeficiencies were more frequent in foreigners (55.8% vs 38.9%, p = 0.03). Substantial differences are noted between native and foreign populations, where 14% and 26% (p < 0.05) respectively have never been vaccinated for COVID-19. Overall, 71% of the referred patients received an early treatment for mild COVID-19, with no differences between the two groups. Overall, on day 28 after treatment, 23 (4%) patients had been hospitalized due to COVID-19 related complications and four died (0,7%), no one was foreigner. In conclusion, while the treatment offered for mild COVID-19 appears to be rather uniform between the native and the foreign populations, some differences, especially in preventive vaccination COVID-19, must be taken into account.
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spelling pubmed-97245522022-12-06 Characteristics of the population with mild COVID-19 symptoms eligible for early treatment attended in a single center in Northern Italy Magro, Paola Degli Antoni, M. Formenti, B. Viola, F. Castelli, F. Amadasi, S. Quiros-Roldan, E. J Infect Public Health Article After more than two years from the first COVID-19 detected case in Brescia, Northern Italy, monoclonal antibodies and antiviral therapy aimed at early treatment of mild COVID-19 in patients at risk of progression and of hospitalization has been approved in Italy. Here we report the characteristics of the population eligible for the COVID-19 early treatments at our COVID-19 Early Therapy Unit of the Infectious Diseases Department of the ASST Spedali Civili of Brescia, with the aim to evaluate the characteristics of the foreign and native groups. Up to March the 31st, 2022, a total of 559 patients were referred to our Unit for COVID-19 early treatment, where 7.6% were foreigners, a group significantly younger than natives (p < 0.05). Particular differences are noticed between the native and the foreign population, where people aged > 65 years old were significantly more frequent among italians (39.7% vs 16.3%, p < 0.01), while primary or acquired immunodeficiencies were more frequent in foreigners (55.8% vs 38.9%, p = 0.03). Substantial differences are noted between native and foreign populations, where 14% and 26% (p < 0.05) respectively have never been vaccinated for COVID-19. Overall, 71% of the referred patients received an early treatment for mild COVID-19, with no differences between the two groups. Overall, on day 28 after treatment, 23 (4%) patients had been hospitalized due to COVID-19 related complications and four died (0,7%), no one was foreigner. In conclusion, while the treatment offered for mild COVID-19 appears to be rather uniform between the native and the foreign populations, some differences, especially in preventive vaccination COVID-19, must be taken into account. The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2023-01 2022-12-06 /pmc/articles/PMC9724552/ /pubmed/36521328 http://dx.doi.org/10.1016/j.jiph.2022.11.027 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Magro, Paola
Degli Antoni, M.
Formenti, B.
Viola, F.
Castelli, F.
Amadasi, S.
Quiros-Roldan, E.
Characteristics of the population with mild COVID-19 symptoms eligible for early treatment attended in a single center in Northern Italy
title Characteristics of the population with mild COVID-19 symptoms eligible for early treatment attended in a single center in Northern Italy
title_full Characteristics of the population with mild COVID-19 symptoms eligible for early treatment attended in a single center in Northern Italy
title_fullStr Characteristics of the population with mild COVID-19 symptoms eligible for early treatment attended in a single center in Northern Italy
title_full_unstemmed Characteristics of the population with mild COVID-19 symptoms eligible for early treatment attended in a single center in Northern Italy
title_short Characteristics of the population with mild COVID-19 symptoms eligible for early treatment attended in a single center in Northern Italy
title_sort characteristics of the population with mild covid-19 symptoms eligible for early treatment attended in a single center in northern italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724552/
https://www.ncbi.nlm.nih.gov/pubmed/36521328
http://dx.doi.org/10.1016/j.jiph.2022.11.027
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