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Variability of Steroid Response Time in Polymyalgia Rheumatica: A Case Report
We present a unique case of a 75-year-old Caucasian female who presented with a two-month history of unrelenting proximal muscle pain and stiffness in the neck, shoulders, and pelvic girdle that lasted for 45 minutes each morning upon waking. Due to clinical suspicion of polymyalgia rheumatica (PMR)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724594/ https://www.ncbi.nlm.nih.gov/pubmed/36483895 http://dx.doi.org/10.7759/cureus.31159 |
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author | Gay, Carter Kihara, Colby Oakley, Katie Patel, Arsh N Akinsoto, O.P. |
author_facet | Gay, Carter Kihara, Colby Oakley, Katie Patel, Arsh N Akinsoto, O.P. |
author_sort | Gay, Carter |
collection | PubMed |
description | We present a unique case of a 75-year-old Caucasian female who presented with a two-month history of unrelenting proximal muscle pain and stiffness in the neck, shoulders, and pelvic girdle that lasted for 45 minutes each morning upon waking. Due to clinical suspicion of polymyalgia rheumatica (PMR), the patient was started on the standard therapy of low-dose glucocorticoid therapy and was noted to have a dramatic improvement in terms of pain, strength, mobility, and range of motion. Current literature shows high variability in the standard response time to treatment. Typical resolution of symptoms occurs within a span of one day to months. The case presented in our study shows symptom resolution as well as marked improvement in muscle strength and mobility within 12 hours. The purpose of this case report is to provide additional information for physicians when considering symptom-resolution time related to low-dose glucocorticoid therapy and PMR. Additionally, we briefly explore the literature on the correlation between giant cell arteritis (GCA) and glucocorticoid therapy for PMR as well as the data associated with adjuvant therapy using immunomodulatory treatment. |
format | Online Article Text |
id | pubmed-9724594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-97245942022-12-07 Variability of Steroid Response Time in Polymyalgia Rheumatica: A Case Report Gay, Carter Kihara, Colby Oakley, Katie Patel, Arsh N Akinsoto, O.P. Cureus Internal Medicine We present a unique case of a 75-year-old Caucasian female who presented with a two-month history of unrelenting proximal muscle pain and stiffness in the neck, shoulders, and pelvic girdle that lasted for 45 minutes each morning upon waking. Due to clinical suspicion of polymyalgia rheumatica (PMR), the patient was started on the standard therapy of low-dose glucocorticoid therapy and was noted to have a dramatic improvement in terms of pain, strength, mobility, and range of motion. Current literature shows high variability in the standard response time to treatment. Typical resolution of symptoms occurs within a span of one day to months. The case presented in our study shows symptom resolution as well as marked improvement in muscle strength and mobility within 12 hours. The purpose of this case report is to provide additional information for physicians when considering symptom-resolution time related to low-dose glucocorticoid therapy and PMR. Additionally, we briefly explore the literature on the correlation between giant cell arteritis (GCA) and glucocorticoid therapy for PMR as well as the data associated with adjuvant therapy using immunomodulatory treatment. Cureus 2022-11-06 /pmc/articles/PMC9724594/ /pubmed/36483895 http://dx.doi.org/10.7759/cureus.31159 Text en Copyright © 2022, Gay et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Gay, Carter Kihara, Colby Oakley, Katie Patel, Arsh N Akinsoto, O.P. Variability of Steroid Response Time in Polymyalgia Rheumatica: A Case Report |
title | Variability of Steroid Response Time in Polymyalgia Rheumatica: A Case Report |
title_full | Variability of Steroid Response Time in Polymyalgia Rheumatica: A Case Report |
title_fullStr | Variability of Steroid Response Time in Polymyalgia Rheumatica: A Case Report |
title_full_unstemmed | Variability of Steroid Response Time in Polymyalgia Rheumatica: A Case Report |
title_short | Variability of Steroid Response Time in Polymyalgia Rheumatica: A Case Report |
title_sort | variability of steroid response time in polymyalgia rheumatica: a case report |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724594/ https://www.ncbi.nlm.nih.gov/pubmed/36483895 http://dx.doi.org/10.7759/cureus.31159 |
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