Crosstalk between cytotoxic CD8+ T cells and stressed cardiomyocytes triggers development of interstitial cardiac fibrosis in hypertensive mouse hearts

AIMS: Cardiac fibrosis is central to heart failure (HF), especially HF with preserved ejection fraction (HFpEF), often caused by hypertension. Despite fibrosis causing diastolic dysfunction and impaired electrical conduction, responsible for arrhythmia-induced sudden cardiac death, the mechanisms ar...

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Detalles Bibliográficos
Autores principales: Brassington, Kurt, Kanellakis, Peter, Cao, Anh, Toh, Ban-Hock, Peter, Karlheinz, Bobik, Alex, Kyaw, Tin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724649/
https://www.ncbi.nlm.nih.gov/pubmed/36483558
http://dx.doi.org/10.3389/fimmu.2022.1040233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724649/
https://www.ncbi.nlm.nih.gov/pubmed/36483558
http://dx.doi.org/10.3389/fimmu.2022.1040233

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