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Two-stage one-pot synthetic strategy for the key triazone-triazole intermediate of ensitrelvir (S-217622), an oral clinical candidate for treating COVID-19

Herein, the preparation of the key triazone-triazole intermediate of ensitrelvir (S-217622) via sequential cyclization and alkylation reaction is described. Firstly, chloromethyl triazole was synthesized through a one-pot tandem process (condensation and cyclization reaction) from commercially avail...

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Detalles Bibliográficos
Autores principales:	Hu, Wei, Zhang, Xiang, Liu, Yuanchang, Liu, Teng, Wen, Jiale, Peng, Xiaopeng, Xie, Xin, Chen, Weiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724693/ https://www.ncbi.nlm.nih.gov/pubmed/36540243 http://dx.doi.org/10.1039/d2ra06841a

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