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Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
Lung transplantation is the optimal treatment for selected patients with end-stage chronic lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has been considered primarily as a manifestation...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724884/ https://www.ncbi.nlm.nih.gov/pubmed/35896274 http://dx.doi.org/10.1183/16000617.0060-2022 |
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author | Bos, Saskia Milross, Luke Filby, Andrew J. Vos, Robin Fisher, Andrew J. |
author_facet | Bos, Saskia Milross, Luke Filby, Andrew J. Vos, Robin Fisher, Andrew J. |
author_sort | Bos, Saskia |
collection | PubMed |
description | Lung transplantation is the optimal treatment for selected patients with end-stage chronic lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has been considered primarily as a manifestation of cellular immune responses. However, in reality, an array of complex, interacting and multifactorial mechanisms contribute to its emergence. Alloimmune-dependent mechanisms, including T-cell-mediated rejection and antibody-mediated rejection, as well as non-alloimmune injuries, have been implicated. Moreover, a role has emerged for autoimmune responses to lung self-antigens in the development of chronic graft injury. The aim of this review is to summarise the immune processes involved in the pathogenesis of chronic lung allograft dysfunction, with advanced insights into the role of innate immune pathways and crosstalk between innate and adaptive immunity, and to identify gaps in current knowledge. |
format | Online Article Text |
id | pubmed-9724884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-97248842022-12-08 Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle Bos, Saskia Milross, Luke Filby, Andrew J. Vos, Robin Fisher, Andrew J. Eur Respir Rev Reviews Lung transplantation is the optimal treatment for selected patients with end-stage chronic lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has been considered primarily as a manifestation of cellular immune responses. However, in reality, an array of complex, interacting and multifactorial mechanisms contribute to its emergence. Alloimmune-dependent mechanisms, including T-cell-mediated rejection and antibody-mediated rejection, as well as non-alloimmune injuries, have been implicated. Moreover, a role has emerged for autoimmune responses to lung self-antigens in the development of chronic graft injury. The aim of this review is to summarise the immune processes involved in the pathogenesis of chronic lung allograft dysfunction, with advanced insights into the role of innate immune pathways and crosstalk between innate and adaptive immunity, and to identify gaps in current knowledge. European Respiratory Society 2022-07-27 /pmc/articles/PMC9724884/ /pubmed/35896274 http://dx.doi.org/10.1183/16000617.0060-2022 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Reviews Bos, Saskia Milross, Luke Filby, Andrew J. Vos, Robin Fisher, Andrew J. Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle |
title | Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle |
title_full | Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle |
title_fullStr | Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle |
title_full_unstemmed | Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle |
title_short | Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle |
title_sort | immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724884/ https://www.ncbi.nlm.nih.gov/pubmed/35896274 http://dx.doi.org/10.1183/16000617.0060-2022 |
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