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Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle

Lung transplantation is the optimal treatment for selected patients with end-stage chronic lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has been considered primarily as a manifestation...

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Detalles Bibliográficos
Autores principales: Bos, Saskia, Milross, Luke, Filby, Andrew J., Vos, Robin, Fisher, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724884/
https://www.ncbi.nlm.nih.gov/pubmed/35896274
http://dx.doi.org/10.1183/16000617.0060-2022
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author Bos, Saskia
Milross, Luke
Filby, Andrew J.
Vos, Robin
Fisher, Andrew J.
author_facet Bos, Saskia
Milross, Luke
Filby, Andrew J.
Vos, Robin
Fisher, Andrew J.
author_sort Bos, Saskia
collection PubMed
description Lung transplantation is the optimal treatment for selected patients with end-stage chronic lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has been considered primarily as a manifestation of cellular immune responses. However, in reality, an array of complex, interacting and multifactorial mechanisms contribute to its emergence. Alloimmune-dependent mechanisms, including T-cell-mediated rejection and antibody-mediated rejection, as well as non-alloimmune injuries, have been implicated. Moreover, a role has emerged for autoimmune responses to lung self-antigens in the development of chronic graft injury. The aim of this review is to summarise the immune processes involved in the pathogenesis of chronic lung allograft dysfunction, with advanced insights into the role of innate immune pathways and crosstalk between innate and adaptive immunity, and to identify gaps in current knowledge.
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spelling pubmed-97248842022-12-08 Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle Bos, Saskia Milross, Luke Filby, Andrew J. Vos, Robin Fisher, Andrew J. Eur Respir Rev Reviews Lung transplantation is the optimal treatment for selected patients with end-stage chronic lung diseases. However, chronic lung allograft dysfunction remains the leading obstacle to improved long-term outcomes. Traditionally, lung allograft rejection has been considered primarily as a manifestation of cellular immune responses. However, in reality, an array of complex, interacting and multifactorial mechanisms contribute to its emergence. Alloimmune-dependent mechanisms, including T-cell-mediated rejection and antibody-mediated rejection, as well as non-alloimmune injuries, have been implicated. Moreover, a role has emerged for autoimmune responses to lung self-antigens in the development of chronic graft injury. The aim of this review is to summarise the immune processes involved in the pathogenesis of chronic lung allograft dysfunction, with advanced insights into the role of innate immune pathways and crosstalk between innate and adaptive immunity, and to identify gaps in current knowledge. European Respiratory Society 2022-07-27 /pmc/articles/PMC9724884/ /pubmed/35896274 http://dx.doi.org/10.1183/16000617.0060-2022 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Reviews
Bos, Saskia
Milross, Luke
Filby, Andrew J.
Vos, Robin
Fisher, Andrew J.
Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
title Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
title_full Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
title_fullStr Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
title_full_unstemmed Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
title_short Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
title_sort immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724884/
https://www.ncbi.nlm.nih.gov/pubmed/35896274
http://dx.doi.org/10.1183/16000617.0060-2022
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