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Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts

Despite exhibiting cardiotoxicity, doxorubicin (DOX) is widely used for cancer treatments. Cardiac fibroblasts (CFs) are important in the pathogenesis of heart failure. This necessitates the study of the effect of DOX on CFs. The impairment of calcium (Ca(2+)) homeostasis is a common mechanism of he...

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Detalles Bibliográficos
Autores principales:	Nemoto, Hiroko, Umemura, Masanari, Suzuki, Fumina, Nagasako, Akane, Nagao, Kagemichi, Hidaka, Yuko, Nakakaji, Rina, Uchida, Keiji, Suzuki, Shinichi, Masuda, Munetaka, Ishikawa, Yoshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9725120/ https://www.ncbi.nlm.nih.gov/pubmed/36472998 http://dx.doi.org/10.1371/journal.pone.0278613

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