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Association between averaged intraoperative nociceptive response index and postoperative complications after lung resection surgery

OBJECTIVES: Since postoperative complications, defined as Clavien–Dindo grade ≥II, correlate with long-term survival after lung resection surgery in patients with primary lung cancer, identification of intraoperative risk factors for postoperative complications is crucial for better perioperative ma...

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Autores principales: Okamoto, Takuma, Matsuki, Yuka, Ogata, Hiroki, Okutani, Hiroai, Ueki, Ryusuke, Kariya, Nobutaka, Tatara, Tsuneo, Hirose, Munetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9725181/
https://www.ncbi.nlm.nih.gov/pubmed/36214634
http://dx.doi.org/10.1093/icvts/ivac258
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author Okamoto, Takuma
Matsuki, Yuka
Ogata, Hiroki
Okutani, Hiroai
Ueki, Ryusuke
Kariya, Nobutaka
Tatara, Tsuneo
Hirose, Munetaka
author_facet Okamoto, Takuma
Matsuki, Yuka
Ogata, Hiroki
Okutani, Hiroai
Ueki, Ryusuke
Kariya, Nobutaka
Tatara, Tsuneo
Hirose, Munetaka
author_sort Okamoto, Takuma
collection PubMed
description OBJECTIVES: Since postoperative complications, defined as Clavien–Dindo grade ≥II, correlate with long-term survival after lung resection surgery in patients with primary lung cancer, identification of intraoperative risk factors for postoperative complications is crucial for better perioperative management. In the present study, we investigated the possible association between intraoperative variables for use in anaesthetic management and Clavien–Dindo grade ≥II. METHODS: In this multi-institutional observational study, consecutive adult patients undergoing video-assisted thoracic surgery for primary lung cancer under general anaesthesia from March 2019 to April 2021 were enrolled. All patients were divided into 2 groups with Clavien–Dindo grade <II and ≥II. Uni- and multivariable analyses were performed to identify intraoperative risk factors. RESULTS: After univariable analysis between patients with Clavien–Dindo grade <II (n = 415) and ≥II (n = 121), multivariable analysis revealed higher averaged nociceptive response (NR) index during surgery (mean NR), male sex, lower body mass index, longer duration of surgery, higher blood loss and lower urine volume, as independent risk factors for postoperative complications. In sensitivity analysis, based on the cut-off value of mean NR for postoperative complications, all patients were divided into high and low mean NR groups. The incidence of postoperative complications was significantly higher in patients with high mean NR (n = 332) than in patients with low mean NR (n = 204; P < 0.001). CONCLUSIONS: Higher mean NR, as intraoperative variables for use in anaesthetic management, is associated with the higher incidence of postoperative complications after primary lung cancer surgery.
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spelling pubmed-97251812022-12-07 Association between averaged intraoperative nociceptive response index and postoperative complications after lung resection surgery Okamoto, Takuma Matsuki, Yuka Ogata, Hiroki Okutani, Hiroai Ueki, Ryusuke Kariya, Nobutaka Tatara, Tsuneo Hirose, Munetaka Interact Cardiovasc Thorac Surg Thoracic OBJECTIVES: Since postoperative complications, defined as Clavien–Dindo grade ≥II, correlate with long-term survival after lung resection surgery in patients with primary lung cancer, identification of intraoperative risk factors for postoperative complications is crucial for better perioperative management. In the present study, we investigated the possible association between intraoperative variables for use in anaesthetic management and Clavien–Dindo grade ≥II. METHODS: In this multi-institutional observational study, consecutive adult patients undergoing video-assisted thoracic surgery for primary lung cancer under general anaesthesia from March 2019 to April 2021 were enrolled. All patients were divided into 2 groups with Clavien–Dindo grade <II and ≥II. Uni- and multivariable analyses were performed to identify intraoperative risk factors. RESULTS: After univariable analysis between patients with Clavien–Dindo grade <II (n = 415) and ≥II (n = 121), multivariable analysis revealed higher averaged nociceptive response (NR) index during surgery (mean NR), male sex, lower body mass index, longer duration of surgery, higher blood loss and lower urine volume, as independent risk factors for postoperative complications. In sensitivity analysis, based on the cut-off value of mean NR for postoperative complications, all patients were divided into high and low mean NR groups. The incidence of postoperative complications was significantly higher in patients with high mean NR (n = 332) than in patients with low mean NR (n = 204; P < 0.001). CONCLUSIONS: Higher mean NR, as intraoperative variables for use in anaesthetic management, is associated with the higher incidence of postoperative complications after primary lung cancer surgery. Oxford University Press 2022-10-10 /pmc/articles/PMC9725181/ /pubmed/36214634 http://dx.doi.org/10.1093/icvts/ivac258 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Thoracic
Okamoto, Takuma
Matsuki, Yuka
Ogata, Hiroki
Okutani, Hiroai
Ueki, Ryusuke
Kariya, Nobutaka
Tatara, Tsuneo
Hirose, Munetaka
Association between averaged intraoperative nociceptive response index and postoperative complications after lung resection surgery
title Association between averaged intraoperative nociceptive response index and postoperative complications after lung resection surgery
title_full Association between averaged intraoperative nociceptive response index and postoperative complications after lung resection surgery
title_fullStr Association between averaged intraoperative nociceptive response index and postoperative complications after lung resection surgery
title_full_unstemmed Association between averaged intraoperative nociceptive response index and postoperative complications after lung resection surgery
title_short Association between averaged intraoperative nociceptive response index and postoperative complications after lung resection surgery
title_sort association between averaged intraoperative nociceptive response index and postoperative complications after lung resection surgery
topic Thoracic
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9725181/
https://www.ncbi.nlm.nih.gov/pubmed/36214634
http://dx.doi.org/10.1093/icvts/ivac258
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