Cargando…
Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study
Human immunodeficiency virus (HIV)-Mycobacterium tuberculosis (MTB) co-infection has become a pressing global public health problem. Although tuberculosis (TB) is both treatable and curable, it has been exacerbated by the HIV/acquired immune deficiency syndrome (AIDS) epidemic. HIV-MTB co-infected p...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726276/ https://www.ncbi.nlm.nih.gov/pubmed/36482608 http://dx.doi.org/10.1097/MD.0000000000032006 |
_version_ | 1784844740285431808 |
---|---|
author | Yang, Ni Chen, Chuang He, Jinge Li, Jing Zhong, Yin |
author_facet | Yang, Ni Chen, Chuang He, Jinge Li, Jing Zhong, Yin |
author_sort | Yang, Ni |
collection | PubMed |
description | Human immunodeficiency virus (HIV)-Mycobacterium tuberculosis (MTB) co-infection has become a pressing global public health problem. Although tuberculosis (TB) is both treatable and curable, it has been exacerbated by the HIV/acquired immune deficiency syndrome (AIDS) epidemic. HIV-MTB co-infected patients have a variety of disease-specific, and treatment-related factors that can adversely affect their treatment outcomes. This study was conducted to assess the outcomes of TB treatment and its associated factors among HIV-MTB co-infected patients in Sichuan, Southwest China. A retrospective study was performed on HIV-MTB co-infected patients who were diagnosed and registered in TB designated hospitals in Sichuan from January 1, 2016, to December 31, 2020. Data were collected from patients’ electronic medical records regarding their demographic, clinical, and social support information, and categorical data, such as sex, were reported using numbers and percentages. χ(2) and t-tests were conducted to compare groups in relation to different levels of medical institutions. A binary logistic regression model was used to identify the factors associated with unsuccessful TB treatment outcomes. For logistic regression analysis performed using an α of 0.05, odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated for various risk factors. A total of 3677 registered HIV-MTB co-infected patients were enrolled. After adjusting for other variables, male, advanced age, receiving TB treatment at the municipal medical institution, being diagnosed with external pulmonary TB, referral or tracing, being sputum smear positive, not initiating antiretroviral therapy (ART) and not using fixed-dose combinations were the main risk factors for treatment failure of HIV-MTB co-infected patients in Sichuan province. Sex, age, hospital level, patient source, other diagnostic factors (e.g., sputum smear results, anatomical site of TB), and factors of therapeutic schemes (e.g., antiretroviral therapy, fixed-dose combinations) may serve as risk factors to estimate the likely treatment outcome of HIV-TB co-infection. |
format | Online Article Text |
id | pubmed-9726276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-97262762022-12-09 Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study Yang, Ni Chen, Chuang He, Jinge Li, Jing Zhong, Yin Medicine (Baltimore) 4900 Human immunodeficiency virus (HIV)-Mycobacterium tuberculosis (MTB) co-infection has become a pressing global public health problem. Although tuberculosis (TB) is both treatable and curable, it has been exacerbated by the HIV/acquired immune deficiency syndrome (AIDS) epidemic. HIV-MTB co-infected patients have a variety of disease-specific, and treatment-related factors that can adversely affect their treatment outcomes. This study was conducted to assess the outcomes of TB treatment and its associated factors among HIV-MTB co-infected patients in Sichuan, Southwest China. A retrospective study was performed on HIV-MTB co-infected patients who were diagnosed and registered in TB designated hospitals in Sichuan from January 1, 2016, to December 31, 2020. Data were collected from patients’ electronic medical records regarding their demographic, clinical, and social support information, and categorical data, such as sex, were reported using numbers and percentages. χ(2) and t-tests were conducted to compare groups in relation to different levels of medical institutions. A binary logistic regression model was used to identify the factors associated with unsuccessful TB treatment outcomes. For logistic regression analysis performed using an α of 0.05, odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated for various risk factors. A total of 3677 registered HIV-MTB co-infected patients were enrolled. After adjusting for other variables, male, advanced age, receiving TB treatment at the municipal medical institution, being diagnosed with external pulmonary TB, referral or tracing, being sputum smear positive, not initiating antiretroviral therapy (ART) and not using fixed-dose combinations were the main risk factors for treatment failure of HIV-MTB co-infected patients in Sichuan province. Sex, age, hospital level, patient source, other diagnostic factors (e.g., sputum smear results, anatomical site of TB), and factors of therapeutic schemes (e.g., antiretroviral therapy, fixed-dose combinations) may serve as risk factors to estimate the likely treatment outcome of HIV-TB co-infection. Lippincott Williams & Wilkins 2022-12-02 /pmc/articles/PMC9726276/ /pubmed/36482608 http://dx.doi.org/10.1097/MD.0000000000032006 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 4900 Yang, Ni Chen, Chuang He, Jinge Li, Jing Zhong, Yin Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study |
title | Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study |
title_full | Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study |
title_fullStr | Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study |
title_full_unstemmed | Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study |
title_short | Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study |
title_sort | treatment outcome and its associated factors among hiv-mtb co-infected patients in sichuan, china: a retrospective study |
topic | 4900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726276/ https://www.ncbi.nlm.nih.gov/pubmed/36482608 http://dx.doi.org/10.1097/MD.0000000000032006 |
work_keys_str_mv | AT yangni treatmentoutcomeanditsassociatedfactorsamonghivmtbcoinfectedpatientsinsichuanchinaaretrospectivestudy AT chenchuang treatmentoutcomeanditsassociatedfactorsamonghivmtbcoinfectedpatientsinsichuanchinaaretrospectivestudy AT hejinge treatmentoutcomeanditsassociatedfactorsamonghivmtbcoinfectedpatientsinsichuanchinaaretrospectivestudy AT lijing treatmentoutcomeanditsassociatedfactorsamonghivmtbcoinfectedpatientsinsichuanchinaaretrospectivestudy AT zhongyin treatmentoutcomeanditsassociatedfactorsamonghivmtbcoinfectedpatientsinsichuanchinaaretrospectivestudy |