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Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study

Human immunodeficiency virus (HIV)-Mycobacterium tuberculosis (MTB) co-infection has become a pressing global public health problem. Although tuberculosis (TB) is both treatable and curable, it has been exacerbated by the HIV/acquired immune deficiency syndrome (AIDS) epidemic. HIV-MTB co-infected p...

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Autores principales: Yang, Ni, Chen, Chuang, He, Jinge, Li, Jing, Zhong, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726276/
https://www.ncbi.nlm.nih.gov/pubmed/36482608
http://dx.doi.org/10.1097/MD.0000000000032006
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author Yang, Ni
Chen, Chuang
He, Jinge
Li, Jing
Zhong, Yin
author_facet Yang, Ni
Chen, Chuang
He, Jinge
Li, Jing
Zhong, Yin
author_sort Yang, Ni
collection PubMed
description Human immunodeficiency virus (HIV)-Mycobacterium tuberculosis (MTB) co-infection has become a pressing global public health problem. Although tuberculosis (TB) is both treatable and curable, it has been exacerbated by the HIV/acquired immune deficiency syndrome (AIDS) epidemic. HIV-MTB co-infected patients have a variety of disease-specific, and treatment-related factors that can adversely affect their treatment outcomes. This study was conducted to assess the outcomes of TB treatment and its associated factors among HIV-MTB co-infected patients in Sichuan, Southwest China. A retrospective study was performed on HIV-MTB co-infected patients who were diagnosed and registered in TB designated hospitals in Sichuan from January 1, 2016, to December 31, 2020. Data were collected from patients’ electronic medical records regarding their demographic, clinical, and social support information, and categorical data, such as sex, were reported using numbers and percentages. χ(2) and t-tests were conducted to compare groups in relation to different levels of medical institutions. A binary logistic regression model was used to identify the factors associated with unsuccessful TB treatment outcomes. For logistic regression analysis performed using an α of 0.05, odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated for various risk factors. A total of 3677 registered HIV-MTB co-infected patients were enrolled. After adjusting for other variables, male, advanced age, receiving TB treatment at the municipal medical institution, being diagnosed with external pulmonary TB, referral or tracing, being sputum smear positive, not initiating antiretroviral therapy (ART) and not using fixed-dose combinations were the main risk factors for treatment failure of HIV-MTB co-infected patients in Sichuan province. Sex, age, hospital level, patient source, other diagnostic factors (e.g., sputum smear results, anatomical site of TB), and factors of therapeutic schemes (e.g., antiretroviral therapy, fixed-dose combinations) may serve as risk factors to estimate the likely treatment outcome of HIV-TB co-infection.
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spelling pubmed-97262762022-12-09 Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study Yang, Ni Chen, Chuang He, Jinge Li, Jing Zhong, Yin Medicine (Baltimore) 4900 Human immunodeficiency virus (HIV)-Mycobacterium tuberculosis (MTB) co-infection has become a pressing global public health problem. Although tuberculosis (TB) is both treatable and curable, it has been exacerbated by the HIV/acquired immune deficiency syndrome (AIDS) epidemic. HIV-MTB co-infected patients have a variety of disease-specific, and treatment-related factors that can adversely affect their treatment outcomes. This study was conducted to assess the outcomes of TB treatment and its associated factors among HIV-MTB co-infected patients in Sichuan, Southwest China. A retrospective study was performed on HIV-MTB co-infected patients who were diagnosed and registered in TB designated hospitals in Sichuan from January 1, 2016, to December 31, 2020. Data were collected from patients’ electronic medical records regarding their demographic, clinical, and social support information, and categorical data, such as sex, were reported using numbers and percentages. χ(2) and t-tests were conducted to compare groups in relation to different levels of medical institutions. A binary logistic regression model was used to identify the factors associated with unsuccessful TB treatment outcomes. For logistic regression analysis performed using an α of 0.05, odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated for various risk factors. A total of 3677 registered HIV-MTB co-infected patients were enrolled. After adjusting for other variables, male, advanced age, receiving TB treatment at the municipal medical institution, being diagnosed with external pulmonary TB, referral or tracing, being sputum smear positive, not initiating antiretroviral therapy (ART) and not using fixed-dose combinations were the main risk factors for treatment failure of HIV-MTB co-infected patients in Sichuan province. Sex, age, hospital level, patient source, other diagnostic factors (e.g., sputum smear results, anatomical site of TB), and factors of therapeutic schemes (e.g., antiretroviral therapy, fixed-dose combinations) may serve as risk factors to estimate the likely treatment outcome of HIV-TB co-infection. Lippincott Williams & Wilkins 2022-12-02 /pmc/articles/PMC9726276/ /pubmed/36482608 http://dx.doi.org/10.1097/MD.0000000000032006 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4900
Yang, Ni
Chen, Chuang
He, Jinge
Li, Jing
Zhong, Yin
Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study
title Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study
title_full Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study
title_fullStr Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study
title_full_unstemmed Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study
title_short Treatment outcome and its associated factors among HIV-MTB co-infected patients in Sichuan, China: A retrospective study
title_sort treatment outcome and its associated factors among hiv-mtb co-infected patients in sichuan, china: a retrospective study
topic 4900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726276/
https://www.ncbi.nlm.nih.gov/pubmed/36482608
http://dx.doi.org/10.1097/MD.0000000000032006
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