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Progress of Psf1 and prospects in the tumor: A review
Partner of Sld5-1(Psf1) is a member of Gins complex, which was discovered in 2003. It consists of the predominantly α-helical A-domain and the massively β-stranded B-domain. Some researches indicate that Psf1 plays a prominent part in DNA replication through cell cycle regulation, and plays a key ro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726354/ https://www.ncbi.nlm.nih.gov/pubmed/36482653 http://dx.doi.org/10.1097/MD.0000000000031811 |
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author | Zhao, Xuekai Duan, Botao Zhou, Lei |
author_facet | Zhao, Xuekai Duan, Botao Zhou, Lei |
author_sort | Zhao, Xuekai |
collection | PubMed |
description | Partner of Sld5-1(Psf1) is a member of Gins complex, which was discovered in 2003. It consists of the predominantly α-helical A-domain and the massively β-stranded B-domain. Some researches indicate that Psf1 plays a prominent part in DNA replication through cell cycle regulation, and plays a key role in early embryo development and tissue regeneration. The overexpression of Psf1 in active proliferating cells is closely correlated with the occurrence of tumors. On the side, tumor cells with high Psf1 expression showed high heterogeneity and poor clinical prognosis. In this review, we will review the research progress of Psf1 in cell cycle regulation, immature cell proliferation and oncology. |
format | Online Article Text |
id | pubmed-9726354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-97263542022-12-09 Progress of Psf1 and prospects in the tumor: A review Zhao, Xuekai Duan, Botao Zhou, Lei Medicine (Baltimore) 5700 Partner of Sld5-1(Psf1) is a member of Gins complex, which was discovered in 2003. It consists of the predominantly α-helical A-domain and the massively β-stranded B-domain. Some researches indicate that Psf1 plays a prominent part in DNA replication through cell cycle regulation, and plays a key role in early embryo development and tissue regeneration. The overexpression of Psf1 in active proliferating cells is closely correlated with the occurrence of tumors. On the side, tumor cells with high Psf1 expression showed high heterogeneity and poor clinical prognosis. In this review, we will review the research progress of Psf1 in cell cycle regulation, immature cell proliferation and oncology. Lippincott Williams & Wilkins 2022-12-02 /pmc/articles/PMC9726354/ /pubmed/36482653 http://dx.doi.org/10.1097/MD.0000000000031811 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 5700 Zhao, Xuekai Duan, Botao Zhou, Lei Progress of Psf1 and prospects in the tumor: A review |
title | Progress of Psf1 and prospects in the tumor: A review |
title_full | Progress of Psf1 and prospects in the tumor: A review |
title_fullStr | Progress of Psf1 and prospects in the tumor: A review |
title_full_unstemmed | Progress of Psf1 and prospects in the tumor: A review |
title_short | Progress of Psf1 and prospects in the tumor: A review |
title_sort | progress of psf1 and prospects in the tumor: a review |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726354/ https://www.ncbi.nlm.nih.gov/pubmed/36482653 http://dx.doi.org/10.1097/MD.0000000000031811 |
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