Prosaposin Reduces α-Synuclein in Cells and Saposin C Dislodges it from Glucosylceramide-enriched Lipid Membranes

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder affecting over 1% of the 65 + age population. Saposin C, a lysosomal protein required for the normal activity of glucocerebrosidase (GCase), may serve as a disease modifier in PD. Saposin C is cleaved from its...

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Detalles Bibliográficos
Autores principales: Kojima, Rika, Zurbruegg, Mark, Li, Tianyi, Paslawski, Wojciech, Zhang, Xiaoqun, Svenningsson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726671/
https://www.ncbi.nlm.nih.gov/pubmed/36152140
http://dx.doi.org/10.1007/s12031-022-02066-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726671/
https://www.ncbi.nlm.nih.gov/pubmed/36152140
http://dx.doi.org/10.1007/s12031-022-02066-y

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