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Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT
The distribution of the thermal neutron flux has a significant impact on the treatment efficacy. We developed an irradiation method of overlapping irradiation fields using intensity modulators for the treatment of superficial tumors with the aim of expanding the indications for accelerator-based bor...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726706/ https://www.ncbi.nlm.nih.gov/pubmed/36149023 http://dx.doi.org/10.1093/jrr/rrac052 |
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author | Sasaki, Akinori Hu, Naonori Takata, Takushi Matsubayashi, Nishiki Sakurai, Yoshinori Suzuki, Minoru Tanaka, Hiroki |
author_facet | Sasaki, Akinori Hu, Naonori Takata, Takushi Matsubayashi, Nishiki Sakurai, Yoshinori Suzuki, Minoru Tanaka, Hiroki |
author_sort | Sasaki, Akinori |
collection | PubMed |
description | The distribution of the thermal neutron flux has a significant impact on the treatment efficacy. We developed an irradiation method of overlapping irradiation fields using intensity modulators for the treatment of superficial tumors with the aim of expanding the indications for accelerator-based boron neutron capture therapy (BNCT). The shape of the intensity modulator was determined and Monte Carlo simulations were carried out to determine the uniformity of the resulting thermal neutron flux distribution. The intensity modulators were then fabricated and irradiation tests were conducted, which resulted in the formation of a uniform thermal neutron flux distribution. Finally, an evaluation of the tumor dose distribution showed that when two irradiation fields overlapped, the minimum tumor dose was 27.4 Gy-eq, which was higher than the tumor control dose of 20 Gy-eq. Furthermore, it was found that the uniformity of the treatment was improved 47% as compared to the treatment that uses a single irradiation field. This clearly demonstrates the effectiveness of this technique and the possibility of expanding the indications to superficially located tumors. |
format | Online Article Text |
id | pubmed-9726706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97267062022-12-08 Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT Sasaki, Akinori Hu, Naonori Takata, Takushi Matsubayashi, Nishiki Sakurai, Yoshinori Suzuki, Minoru Tanaka, Hiroki J Radiat Res Regular paper The distribution of the thermal neutron flux has a significant impact on the treatment efficacy. We developed an irradiation method of overlapping irradiation fields using intensity modulators for the treatment of superficial tumors with the aim of expanding the indications for accelerator-based boron neutron capture therapy (BNCT). The shape of the intensity modulator was determined and Monte Carlo simulations were carried out to determine the uniformity of the resulting thermal neutron flux distribution. The intensity modulators were then fabricated and irradiation tests were conducted, which resulted in the formation of a uniform thermal neutron flux distribution. Finally, an evaluation of the tumor dose distribution showed that when two irradiation fields overlapped, the minimum tumor dose was 27.4 Gy-eq, which was higher than the tumor control dose of 20 Gy-eq. Furthermore, it was found that the uniformity of the treatment was improved 47% as compared to the treatment that uses a single irradiation field. This clearly demonstrates the effectiveness of this technique and the possibility of expanding the indications to superficially located tumors. Oxford University Press 2022-09-22 /pmc/articles/PMC9726706/ /pubmed/36149023 http://dx.doi.org/10.1093/jrr/rrac052 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular paper Sasaki, Akinori Hu, Naonori Takata, Takushi Matsubayashi, Nishiki Sakurai, Yoshinori Suzuki, Minoru Tanaka, Hiroki Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT |
title | Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT |
title_full | Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT |
title_fullStr | Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT |
title_full_unstemmed | Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT |
title_short | Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT |
title_sort | intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based bnct |
topic | Regular paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726706/ https://www.ncbi.nlm.nih.gov/pubmed/36149023 http://dx.doi.org/10.1093/jrr/rrac052 |
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